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Prenatal exposure t...
Prenatal exposure to paracetamol/acetaminophen and precursor aniline impairs masculinisation of male brain and behaviour
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- Hay-Schmidt, Anders (author)
- Univ Copenhagen
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- Finkielman, Olivia T. Ejlstrup (author)
- Univ Copenhagen
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- Jensen, Benjamin A. H. (author)
- Univ Copenhagen
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- Hogsbro, Christine F. (author)
- Univ Copenhagen
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- Holm, Jacob Bak (author)
- Univ Copenhagen
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- Johansen, Kristoffer Haurum (author)
- Univ Copenhagen
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- Jensen, Tina Kold (author)
- Univ Copenhagen
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- Andrade, Anderson Martino (author)
- Univ Fed Parana, Dept Physiol, Curitiba, Parana, Brazil
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- Swan, Shanna H. (author)
- Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, New York, NY
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- Bornehag, Carl-Gustaf, 1957- (author)
- Karlstads universitet,Institutionen för hälsovetenskaper (from 2013)
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- Brunak, Soren (author)
- Univ Copenhagen
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- Jegou, Bernard (author)
- INSERM, IRSET, U1085, Rennes, France; EHESP Sch Publ Hlth, Rennes, France
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- Kristiansen, Karsten (author)
- Univ Copenhagen
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- Kristensen, David Mobjerg (author)
- INSERM, IRSET Rennes ;Univ Copenhagen
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(creator_code:org_t)
- Bioscientifica, 2017
- 2017
- English.
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In: Reproduction. - : Bioscientifica. - 1470-1626 .- 1476-3990. ; 154:2, s. 145-152
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Paracetamol/acetaminophen (N-Acetyl-p-Aminophenol; APAP) is the preferred analgesic for pain relief and fever during pregnancy. It has therefore caused concern that several studies have reported that prenatal exposure to APAP results in developmental alterations in both the reproductive tract and the brain. Genitals and nervous system of male mammals are actively masculinised during foetal development and early postnatal life by the combined actions of prostaglandins and androgens, resulting in the male-typical reproductive behaviour seen in adulthood. Both androgens and prostaglandins are known to be inhibited by APAP. Through intrauterine exposure experiments in C57BL/6 mice, we found that exposure to APAP decreased neuronal number in the sexually dimorphic nucleus (SDN) of the preoptic area (POA) in the anterior hypothalamus of male adult offspring. Likewise, exposure to the environmental pollutant and precursor of APAP, aniline, resulted in a similar reduction. Decrease in neuronal number in the SDNPOA is associated with reductions in male sexual behaviour. Consistent with the changes, male mice exposed in uteri to APAP exhibited changes in urinary marking behaviour as adults and had a less aggressive territorial display towards intruders of the same gender. Additionally, exposed males had reduced intromissions and ejaculations during mating with females in oestrus. Together, these data suggest that prenatal exposure to APAP may impair male sexual behaviour in adulthood by disrupting the sexual neurobehavioral programming. These findings add to the growing body of evidence suggesting the need to limit the widespread exposure and use of APAP by pregnant women.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Public Health Science
- Folkhälsovetenskap
Publication and Content Type
- ref (subject category)
- art (subject category)
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Hay-Schmidt, And ...
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Finkielman, Oliv ...
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Jensen, Benjamin ...
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Hogsbro, Christi ...
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Holm, Jacob Bak
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Johansen, Kristo ...
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Jensen, Tina Kol ...
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Andrade, Anderso ...
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Swan, Shanna H.
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Bornehag, Carl-G ...
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Brunak, Soren
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Jegou, Bernard
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Kristiansen, Kar ...
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Kristensen, Davi ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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- Articles in the publication
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Reproduction
- By the university
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Karlstad University