Effect of avocado/soybean unsaponifiables on ligature-induced bone loss and bone repair after ligature removal in rats

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Effect of avocado/soybean unsaponifiables on ligature-induced bone loss and bone repair after ligature removal in rats

Oliveira, G. J. P. L. (author): Section of Periodontology, Department of Diagnosis and Surgery, Araraquara School of Dentistry, University Estadual Paulista - UNESP, Araraquara, SP, Brazil

Paula, L. G. F (author): Section of Periodontology, Department of Diagnosis and Surgery, Araraquara School of Dentistry, University Estadual Paulista - UNESP, Araraquara, SP, Brazil

Souza, J. A. C (author): Section of Periodontology, Department of Diagnosis and Surgery, Araraquara School of Dentistry, University Estadual Paulista - UNESP, Araraquara, SP, Brazil

Spin-Neto, R (author): Section of Oral Radiology, Department of Dentistry, Aarhus University, Aarhus, Denmark

Stavropoulos, Andreas (author): Malmö högskola,Odontologiska fakulteten (OD)

Marcantonio, R. A. C (author): Section of Periodontology, Department of Diagnosis and Surgery, Araraquara School of Dentistry, University Estadual Paulista - UNESP, Araraquara, SP, Brazil

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2015-08-06
2016
English.
In: Journal of Periodontal Research. - : Wiley-Blackwell Publishing Inc.. - 0022-3484 .- 1600-0765. ; 51:3, s. 332-341

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background and ObjectiveThe aim of this study was to evaluate the effects of administration of avocado/soybean unsaponifiable (ASU), a drug that is commonly used in the treatment of rheumatoid arthritis, on ligature-induced bone loss and bone repair after ligature removal in rats. Material and MethodsEighty-four rats were randomly assigned to four groups of equal size and received a daily gavageof either sterile saline [control (CTR)] or ASU (0.6mg/kg), starting 7d before (ASU/-7), on the day of (ASU/0) or 7d after (ASU/+7) periodontitis induction. Periodontitis was induced by placing silk ligatures into the gingival sulcus of the second maxillary molars for 7d; after 7d, the ligatures were removed. Seven rats from each group were sacrificed, 7, 15 or 30d after ligature removal. Bone resorption was evaluated by histomorphometry and micro-computed tomography (micro-CT). Immunohistochemistry was used to evaluate the expression of TRAP, RANKL and alkaline phosphatase (ALP), and quantitative PCR (qPCR) was used to evaluate the levels of interleukin-1beta (Il1), tumor necrosis factor alpha (Tnf), interleukin-6 (Il-6), Rankl and Alp. Statistical analysis was performed using the Shapiro-Wilk test, ANOVA and Tukey's test for normal data, and using the Kruskall-Wallis and Dunnet's tests for non-normal data (p<0.05 ResultsHistomorphometry and micro-CT analysis showed greater bone resorption in the CTR group than in the ASU/0 (15d) and ASU/+7 (7 and 15d) groups. The CTR group also presented with a higher expression of TRAP (15 and 30d) and RANKL (7 and 15d) compared with ASU/0 and ASU/+7 groups. Similarly, qPCR analysis showed higher levels of Rankl and Il1 mRNAs, and lower levels of Alp mRNA, in the CTR group compared with all other groups (for all periods ConclusionASU exhibited a positive effect on bone repair following ligature-induced periodontitis in rats

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)

Keyword

animal studies
avocado
soybean unsaponifiables
host modulation
periodontitis

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ref (subject category)
art (subject category)

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Dentistry

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By the university: Malmö University

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