Spatial confinement of ultrasonic force fields in microfluidic chips

Manneberg, Otto, 1981- (author): KTH,Tillämpad fysik,Biomedical & X-Ray Physics

Svennebring, Jessica (author): KTH,Tillämpad fysik,Biomedical & X-Ray Physics

(creator_code:org_t)

Elsevier BV, 2009
2009
English.
In: Ultrasonics. - : Elsevier BV. - 0041-624X .- 1874-9968. ; 49, s. 112-119

Related links:: http://www.sciencedi...; show more...; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Abstract Subject headings

We demonstrate and investigate multiple localized ultrasonic manipulation functions in series in microfluidic chips. The manipulation functions are based on spatially separated and confined ultrasonic primary radiation force fields, obtained by local matching of the resonance condition of the microfluidic channel. The channel segments are remotely actuated by the use of frequency-specific external transducers with refracting wedges placed on top of the chips. The force field in each channel segment is characterized by the use of micrometer-resolution particle image velocimetry ( micro-PIV). The confinement of the ultrasonic fields during single-or dual-segment actuation, as well as the cross-talk between two adjacent. fields, is characterized and quantified. Our results show that the field confinement typically scales with the acoustic wavelength, and that the cross-talk is insignificant between adjacent. fields. The goal is to define design strategies for implementing several spatially separated ultrasonic manipulation functions in series for use in advanced particle or cell handling and processing applications. One such proof-of-concept application is demonstrated, where. flow-through-mode operation of a chip with. flow splitting elements is used for two-dimensional pre-alignment and addressable merging of particle tracks.

By the author/editor: Manneberg, Otto, ...; Hagsäter, S. Mel ...; Svennebring, Jes ...; Hertz, Hans M.; Kutter, Jörg P.; Bruus, Henrik; show more...; Wiklund, Martin; show less...

About the subject

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