MRI manifestation of novel superparamagnetic iron oxide nanoparticles in the rat inner ear

(creator_code:org_t)

Future Medicine Ltd, 2010
2010
English.
In: Nanomedicine. - : Future Medicine Ltd. - 1743-5889 .- 1748-6963. ; 5:5, s. 739-754

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.2...; show less...

Abstract Subject headings

Aim: Superparamagnetic iron oxide nanoparticles hierarchically coated with oleic acid and Pluronic F127 copolymers (POA@SPION) have shown exceptional 12 contrast enhancement. The aim of the present work was to investigate the MRI manifestation of POA@SPION in the inner ear. Materials & methods: A total of 26 male Wister rats were selected for testing POA@SPION administered through intracochlear, intratympanic and intravenous routes. MRI was performed with a 4.7 T MR scanner. Results & conclusion: POA@SPION can be introduced into the perilymph space, after which it becomes widely distributed and can demonstrate the integrity of the perilymph-endolymph barrier. Positive highlighting of the endolymph compartment against the darkened perilymph was visualized for the first time. POA@SPION passed through the middle-inner ear barriers in only small amounts, but stayed in the perilymph for 3 days. They did not traverse the blood-perilymph barrier or blood-endolymph barrier. The inner ear distribution of POA@SPION was confirmed by histology. POA@SPION is a promising T2 negative contrast agent.

TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk laboratorie- och mätteknik (hsv//swe)
ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Laboratory and Measurements Technologies (hsv//eng)

By the author/editor: Zhou, Jing; Zhang, Weikai; Poe, Dennis; Qin, Jian; Fornara, Andrea; Zhang, Ya; show more...; Ramadan, Usama; Muhammed, Mamoun; Pyykkö, Ilmari; show less...

About the subject

ENGINEERING AND TECHNOLOGY: ENGINEERING AND ...; and Medical Engineer ...; and Medical Laborato ...

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