Fluoride-Promoted Esterification with Imidazolide-Activated Compounds: A Modular and Sustainable Approach to Dendrimers

Fluoride-Promoted Esterification with Imidazolide-Activated Compounds : A Modular and Sustainable Approach to Dendrimers

Garcia Gallego, Sandra (author)

(creator_code:org_t)

2015-01-21
2015
English.
In: Angewandte Chemie International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 54:8, s. 2416-2419

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; show less...

Abstract Subject headings

Based on the growing demand for facile and sustainable synthetic methods to structurally perfect polymers, we herein describe a significant improvement of esterification reactions capitalizing on 1,1-carbonyldiimidazole (CDI). Cesium fluoride was shown to be an essential catalyst for these reactions to reach completion. This approach was successfully applied to the synthesis of structurally flawless and highly functional polyester dendrimers employing traditional and accelerated growth strategies. A sixth generation bis-MPA dendrimer with a molecular weight of 22.080Da and 192 peripheral hydroxy groups was isolated in less than one day of total reaction time. Large quantities of dendrimerswere obtained in high yields (>90%) using simple purification steps under sustainable conditions. The fluoride-promoted esterification (FPE) via imidazolide-activated compounds is wide in scope and constitutes a potentially new approach toward functional polymers and other materials.

By the author/editor: Garcia Gallego, ...; Hult, Daniel; Olsson, Johan V.; Malkoch, Michael

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Chemical Science ...; and Polymer Chemistr ...

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