id:"swepub:oai:DiVA.org:kth-16385"
Search: id:"swepub:oai:DiVA.org:kth-16385" > A hemicord locomoto...
- 1 of 1
- Previous record
- Next record
- To hitlist
A hemicord locomotor network of excitatory interneurons : a simulation study
-
- Kozlov, Alexander K. (author)
- Karolinska Institutet,KTH,Beräkningsbiologi, CB
-
- Lansner, Anders (author)
- KTH,Beräkningsbiologi, CB
-
- Grillner, S. (author)
- Karolinska Institutet
- show more...
- show less...
- (creator_code:org_t)
- 2006-12-19
- 2007
- English.
- In: Biological Cybernetics. - : Springer Science and Business Media LLC. - 0340-1200 .- 1432-0770. ; 96:2, s. 229-243
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Locomotor burst generation is simulated using a full-scale network model of the unilateral excitatory interneuronal population. Earlier small-scale models predicted that a population of excitatory neurons would be sufficient to produce burst activity, and this has recently been experimentally confirmed. Here we simulate the hemicord activity induced under various experimental conditions, including pharmacological activation by NMDA and AMPA as well as electrical stimulation. The model network comprises a realistic number of cells and synaptic connectivity patterns. Using similar distributions of cellular and synaptic parameters, as have been estimated experimentally, a large variation in dynamic characteristics like firing rates, burst, and cycle durations were seen in single cells. On the network level an overall rhythm was generated because the synaptic interactions cause partial synchronization within the population. This network rhythm not only emerged despite the distributed cellular parameters but relied on this variability, in particular, in reproducing variations of the activity during the cycle and showing recruitment in interneuronal populations. A slow rhythm (0.4-2 Hz) can be induced by tonic activation of NMDA-sensitive channels, which are voltage dependent and generate depolarizing plateaus. The rhythm emerges through a synchronization of bursts of the individual neurons. A fast rhythm (4-12 Hz), induced by AMPA, relies on spike synchronization within the population, and each burst is composed of single spikes produced by different neurons. The dynamic range of the fast rhythm is limited by the ability of the network to synchronize oscillations and depends on the strength of synaptic connections and the duration of the slow after hyperpolarization. The model network also produces prolonged bouts of rhythmic activity in response to brief electrical activations, as seen experimentally. The mutual excitation can sustain long-lasting activity for a realistic set of synaptic parameters. The bout duration depends on the strength of excitatory synaptic connections, the level of persistent depolarization, and the influx of Ca2+ ions and activation of Ca2+-dependent K+ current.
Subject headings
- NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
Keyword
- lamprey spinal-cord
- amino-acid receptors
- intersegmental phase-lag
- computer-based model
- rhythm generation
- xenopus-embryos
- reticulospinal neurons
- realistic simulations
- fictive locomotion
- neural networks
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Biological Cybernetics (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Kozlov, Alexande ...
- Lansner, Anders
- Grillner, S.
- Hellgren Kotales ...
- About the subject
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Computer and Inf ...
- and Bioinformatics
- Articles in the publication
- Biological Cyber ...
- By the university
- Royal Institute of Technology
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
