Carbohydrate conjugation through microwave-assisted functionalization of single-walled carbon nanotubes using perfluorophenyl azides

Kong, Na (författare): KTH,Organisk kemi,Royal Institute of Technology, Department of Chemistry

Shimpi, Manishkumar R. (författare): KTH,Organisk kemi,Royal Institute of Technology, Department of Chemistry

Park, Jae Hyeung (författare): Department of Chemistry, University of Massachusetts, Lowell

Ramström, Olof (författare): KTH,Organisk kemi,Organic Chemistry, School of Chemical Science and Engineering, KTH – Royal Institute of Technology, Stockholm, Royal Institute of Technology, Department of Chemistry

Yan, Mingdi (författare): KTH,Organisk kemi,Royal Institute of Technology, Department of Chemistry

(creator_code:org_t)

Elsevier BV, 2015
2015
Engelska.
Ingår i: Carbohydrate Research. - : Elsevier BV. - 0008-6215 .- 1873-426X. ; 405, s. 33-38

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Abstract Ämnesord

Stäng

Carbohydrate-functionalized single-walled carbon nanotubes (SWNTs) were synthesized using microwave-assisted reaction of perfluorophenyl azide with the nanotubes. The results showed that microwave radiation provides a rapid and effective means to covalently attach carbohydrates to SWNTs, producing carbohydrate-SWNT conjugates for biorecognition. The carbohydrate-functionalized SWNTs were furthermore shown to interact specifically with cognate carbohydrate-specific proteins (lectins), resulting in predicted recognition patterns. The carbohydrate-presenting SWNTs constitute a new platform for sensitive protein-or cell recognition, which pave the way for glycoconjugated carbon nanomaterials in biorecognition applications.

Av författaren/redakt...: Kong, Na; Shimpi, Manishku ...; Park, Jae Hyeung; Ramström, Olof; Yan, Mingdi

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