Long-range recruitment of Martinotti cells causes surround suppression and promotes saliency in an attractor network model

Krishnamurthy, Pradeep (author): Stockholms universitet,KTH,Beräkningsbiologi, CB,Stockholm University, Sweden,Numerisk analys och datalogi (NADA),Royal Institute of Technology (KTH), Sweden

Lansner, Anders (author): Stockholms universitet,KTH,Beräkningsbiologi, CB,Stockholm University, Sweden,Numerisk analys och datalogi (NADA),Royal Institute of Technology (KTH), Sweden

(creator_code:org_t)

2015-10-14
2015
English.
In: Frontiers in Neural Circuits. - : Frontiers Media SA. - 1662-5110. ; 9

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Abstract Subject headings

Although the importance of long-range connections for cortical information processing has been acknowledged for a long time, most studies focused on the long-range interactions between excitatory cortical neurons. Inhibitory interneurons play an important role in cortical computation and have thus far been studied mainly with respect to their local synaptic interactions within the cortical microcircuitry. A recent study showed that long-range excitatory connections onto Martinotti cells (MC) mediate surround suppression. Here we have extended our previously reported attractor network of pyramidal cells (PC) and MC by introducing long-range connections targeting MC. We have demonstrated how the network with Martinotti cell-mediated long-range inhibition gives rise to surround suppression and also promotes saliency of locations at which simple non-uniformities in the stimulus field are introduced. Furthermore, our analysis suggests that the presynaptic dynamics of MC is only ancillary to its orientation tuning property in enabling the network with saliency detection. Lastly, we have also implemented a disinhibitory pathway mediated by another interneuron type (VIP interneurons), which inhibits MC and abolishes surround suppression.

NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)

By the author/editor: Krishnamurthy, P ...; Silberberg, Gila ...; Lansner, Anders

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Computer and Inf ...; and Bioinformatics

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

By the university: Royal Institute of Technology; Karolinska Institutet; Stockholm University

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