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An efficient enzymatic aminolysis for kinetic resolution of aromatic alpha-hydroxyl acid in non-aqueous media
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- Chen, Shan (author)
- KTH,Industriell bioteknologi,Hainan University, China
- Liu, Fuyan (author)
- Zhang, Kuan (author)
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- Huang, Hansheng (author)
- Wang, Huani (author)
- Zhou, Jiaying (author)
- Zhang, Jing (author)
- Gong, Yiwei (author)
- Zhang, Dela (author)
- Chen, Yiping (author)
- Lin, Chang (author)
- Wang, Bo (author)
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- (creator_code:org_t)
- Elsevier, 2016
- 2016
- English.
- In: Tetrahedron Letters. - : Elsevier. - 0040-4039 .- 1359-8562. ; 57:48, s. 5312-5314
- Journal article (peer-reviewed)
Abstract
Subject headings
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- A new and highly efficient enzymatic aminolysis approach for kinetic resolution of aromatic a-hydroxy acid in non-aqueous media has been developed. The corresponding alpha-hydroxyl acid ester was employed as the substrate, and commercially available Candida antarctica lipase B is used as the biocatalyst, anhydrous ammonia is the resolving agent. Reactions can be proceeded smoothly in organic solvent at ambient temperatures. High concentration of substrate is allowed due to the application of organic media and the products are obtained in yields of up to 49% with ee values of up to 99%, and with E value of >300, representing an appealing and promising protocol for large-scale preparations.
Subject headings
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Keyword
- Ammonia
- Aminolysis
- Kinetic resolution
- Lipase
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
- Chen, Shan
- Liu, Fuyan
- Zhang, Kuan
- Huang, Hansheng
- Wang, Huani
- Zhou, Jiaying
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- Zhang, Jing
- Gong, Yiwei
- Zhang, Dela
- Chen, Yiping
- Lin, Chang
- Wang, Bo
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- About the subject
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- NATURAL SCIENCES
- NATURAL SCIENCES
- and Chemical Science ...
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- Tetrahedron Lett ...
- By the university
- Royal Institute of Technology
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