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Total synthesis of ...
Total synthesis of homogeneous variants of hirudin P6 : a post-translationally modified anti-thrombotic leech-derived protein
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- Hsieh, Yves S. Y. (author)
- University of Sydney, Australia
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Wijeyewickrema, Lakshmi C. (author)
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Wilkinson, Brendan L. (author)
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Pike, Robert N. (author)
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Payne, Richard J. (author)
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(creator_code:org_t)
- 2014-03-11
- 2014
- English.
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In: Angewandte Chemie International Edition. - : Wiley-VCH Verlagsgesellschaft. - 1433-7851 .- 1521-3773. ; 53:15, s. 3947-51
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Hirudin P6 is a leech-derived anti-thrombotic protein which possesses two post-translational modifications, O-glycosylation and tyrosine sulfation. In this study we report the ligation-based synthesis of a library of hirudin P6 proteins possessing homogeneous glycosylation and sulfation modifications. The nature of the modifications incorporated was shown to have a drastic effect on inhibition against both the fibrinogenolytic and amidolytic activities of thrombin and thus highlights a potential means for attenuating the biological activity of the protein.
Subject headings
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Keyword
- glycoprotein
- glycosylation
- ligation
- sulfation
- sulfoprotein
Publication and Content Type
- ref (subject category)
- art (subject category)
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