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Elevated levels of ...
Elevated levels of insulin-like growth factor-binding protein 1 predict outcome after acute myocardial infarction : A long-term follow-up of the glucose tolerance in patients with acute myocardial infarction (GAMI) cohort
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- Ritsinger, V. (författare)
- Karolinska Institutet
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- Brismar, K. (författare)
- Karolinska Institutet
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- Mellbin, L. (författare)
- Karolinska Institutet
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- Näsman, Per (författare)
- KTH,Fastighetsekonomi och finans
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- Rydén, L. (författare)
- Karolinska Institutet
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- Söderberg, Stefan (författare)
- Umeå universitet,Kardiologi
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- Norhammar, A. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2018-07-11
- 2018
- Engelska.
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Ingår i: Diabetes & Vascular Disease Research. - : SAGE Publications Ltd. - 1479-1641 .- 1752-8984. ; 15:5, s. 387-395
- Relaterad länk:
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Objective: To investigate the long-term prognostic value of insulin-like growth factor-binding protein 1 in patients with acute myocardial infarction. Methods: Patients (n = 180) with admission glucose < 11 mmol/L without previously known diabetes admitted for an acute myocardial infarction in 1998–2000 were followed for mortality and cardiovascular events (first of cardiovascular mortality/acute myocardial infarction/stroke/severe heart failure) until the end of 2011 (median 11.6 years). Fasting levels of insulin-like growth factor-binding protein 1 at day 2 were related to outcome in Cox proportional hazard regression analyses. Results: Median age was 64 years, 69% were male and median insulin-like growth factor-binding protein 1 was 20 µg/L. Total mortality was 34% (n = 61) and 44% (n = 80) experienced a cardiovascular event during a median follow-up time of 11.6 years. After age adjustment, insulin-like growth factor-binding protein 1 was associated with all-cause (1.40; 1.02–1.93, p = 0.039) and cancer mortality (2.09; 1.15–3.79, p = 0.015) but not with cardiovascular death (p = 0.29) or cardiovascular events (p = 0.57). After adjustments also for previous myocardial infarction, previous heart failure and body mass index, insulin-like growth factor-binding protein 1 was still associated with all-cause mortality (1.38; 1.01–1.89, p = 0.046). Conclusion: In patients with acute myocardial infarction without previously known diabetes, high insulin-like growth factor-binding protein 1 was associated with long-term all-cause and cancer mortality but not with cardiovascular events.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- abnormal glucose tolerance
- Acute myocardial infarction
- insulin-like growth factor-binding protein 1
- prognosis
- glucose
- hemoglobin A1c
- insulin
- lipid
- proinsulin
- somatomedin binding protein 1
- somatomedin C
- biological marker
- IGFBP1 protein
- human
- acute heart infarction
- adult
- aged
- all cause mortality
- Article
- body mass
- cancer mortality
- cardiovascular mortality
- cerebrovascular accident
- cohort analysis
- controlled study
- disease severity
- fasting
- female
- follow up
- glucose blood level
- glucose tolerance
- heart failure
- hospital admission
- human
- insulin blood level
- lipid blood level
- long term care
- major clinical study
- male
- outcome assessment
- protein blood level
- blood
- cause of death
- chi square distribution
- disease exacerbation
- heart infarction
- Kaplan Meier method
- metabolism
- middle aged
- mortality
- neoplasm
- proportional hazards model
- risk factor
- time factor
- upregulation
- Biomarkers
- Blood Glucose
- Chi-Square Distribution
- Disease Progression
- Follow-Up Studies
- Humans
- Insulin-Like Growth Factor Binding Protein 1
- Kaplan-Meier Estimate
- Myocardial Infarction
- Neoplasms
- Proportional Hazards Models
- Risk Factors
- Time Factors
- Up-Regulation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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