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The cholinergic anti-inflammatory pathway in resistant hypertension treated with renal denervation
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- Hilderman, Marie (author)
- Karolinska Institutet
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- Qureshi, Abdul Rashid (author)
- Karolinska Institutet
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- Abtahi, Farhad, 1981- (author)
- Karolinska Institutet
- show more...
- Jägren, Christina (author)
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- (creator_code:org_t)
- 2019-08-15
- 2019
- English.
- In: Molecular Medicine. - : Springer Science and Business Media LLC. - 1076-1551 .- 1528-3658. ; 25:1
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Renal denervation (RDN) reduces sympathetic tone and may alter the sympathetic-parasympathetic balance. The autonomic nervous system is partly a regulator of innate immunity via the cholinergic anti-inflammatory pathway (CAP) which inhibits inflammation via the vagus nerve. Placental Growth Factor (PlGF) influences a neuro-immunological pathway in the spleen which may contribute to hypertension. The aim of this study was to investigate if modulation of renal sympathetic nerve activity affects CAP in terms of cytokine release as well as levels of PlGF.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Annan medicinteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Other Medical Engineering (hsv//eng)
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- art (subject category)
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