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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03922naa a2200613 4500 | |
| 001 | oai:DiVA.org:kth-287132 | |
| 003 | SwePub | |
| 008 | 201207s2020 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:144396035 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2871322 URI |
| 024 | 7 | a https://doi.org/10.1002/mds.281922 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1443960352 URI |
| 040 | a (SwePub)kthd (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Markaki, I.u Karolinska Institutet4 aut |
| 245 | 1 0 | a Cerebrospinal Fluid Levels of Kininogen-1 Indicate Early Cognitive Impairment in Parkinson’s Disease |
| 264 | c 2020-08-15 | |
| 264 | 1 | b John Wiley & Sons,c 2020 |
| 338 | a print2 rdacarrier | |
| 500 | a QCR 202007 | |
| 520 | a Background: Cognitive impairment is common in patients with PD. Core markers of Alzheimer’s dementia have been related also to PD dementia, but no disease-specific signature to predict PD dementia exists to date. Objectives: The aim of this study was to investigate CSF markers associated with cognition in early PD. Methods: A high-throughput suspension bead array examined 216 proteins in CSF of 74 PD patients in the AETIONOMY project. Cognitive function was assessed with Repeatable Battery for the Assessment of the Neuropsychological Status, Montreal Cognitive Assessment, and Mini-Mental State Examination. Results: Of 69 patients with complete data, 34 had high (≥90) and 35 had low Repeatable Battery for the Assessment of the Neuropsychological Status total score (<90). Of 14 proteins in CSF that differed in levels between groups, increased kininogen-1, validated with several antibodies, was independently associated with lower Repeatable Battery for the Assessment of the Neuropsychological Status and Montreal Cognitive Assessment scores after adjustment for confounders. Conclusions: Kininogen-1 levels in CSF may serve as a marker of cognitive impairment in PD. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 653 | a cognition | |
| 653 | a kininogen-1 | |
| 653 | a neurodegeneration | |
| 653 | a Parkinson’s disease | |
| 700 | 1 | a Bergström, Sofiau KTH,Affinitets-proteomik4 aut0 (Swepub:kth)u1ugb8pi |
| 700 | 1 | a Tsitsi, P.u Karolinska Institutet4 aut |
| 700 | 1 | a Remnestål, Juliau KTH,Affinitets-proteomik4 aut0 (Swepub:kth)u13wztpi |
| 700 | 1 | a Månberg, Anna,d 1985-u KTH,Affinitets-proteomik4 aut0 (Swepub:kth)u1g5roxd |
| 700 | 1 | a Hertz, E.4 aut |
| 700 | 1 | a Paslawski, W.u Karolinska Institutet4 aut |
| 700 | 1 | a Sorjonen, K.u Karolinska Institutet4 aut |
| 700 | 1 | a Uhlén, Mathiasu Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden4 aut0 (Swepub:kth)u1dulvmw |
| 700 | 1 | a Mangone, G.4 aut |
| 700 | 1 | a Carvalho, S.4 aut |
| 700 | 1 | a Rascol, O.4 aut |
| 700 | 1 | a Meissner, W. G.4 aut |
| 700 | 1 | a Magnin, E.4 aut |
| 700 | 1 | a Wüllner, U.4 aut |
| 700 | 1 | a Corvol, J. -C4 aut |
| 700 | 1 | a Nilsson, Peteru KTH,Affinitets-proteomik4 aut0 (Swepub:kth)u1ws88sk |
| 700 | 1 | a Svenningsson, P.u Karolinska Institutet4 aut |
| 710 | 2 | a Karolinska Institutetb Affinitets-proteomik4 org |
| 773 | 0 | t Movement Disordersd : John Wiley & Sonsx 0885-3185x 1531-8257 |
| 856 | 4 | u https://doi.org/10.1002/mds.28192y Fulltext |
| 856 | 4 | u https://movementdisorders.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mds.28192 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-287132 |
| 856 | 4 8 | u https://doi.org/10.1002/mds.28192 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:144396035 |
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