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Quantitative MRI using relaxometry in malignant gliomas detects contrast enhancement in peritumoral oedema

Blystad, Ida, 1972- (author)
Linköpings universitet,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Avdelningen för diagnostik och specialistmedicin,Region Östergötland, Röntgenkliniken i Linköping
Warntjes, Marcel, Jan Bertus, 1973- (author)
Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV
Smedby, Örjan, Professor, 1956- (author)
Linköpings universitet,KTH,Medicinsk avbildning,Linköping Univ, Dept Radiol Linköping, Linköping, Sweden.;Linköping Univ, Dept Hlth Med & Caring Sci, Linköping, Sweden.;Linköping Univ, Ctr Med Image Sci & Visualizat CMIV, Linköping, Sweden.,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Röntgenkliniken i Linköping,School of Technology and Health, KTH Royal Institute of Technology, Stockholm, Sweden
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Lundberg, Peter, 1958- (author)
Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Medicinsk strålningsfysik
Larsson, Elna-Marie (author)
Uppsala universitet,Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinska fakulteten,Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden,Radiologi,Centre for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden
Tisell, Anders, 1981- (author)
Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Medicinsk strålningsfysik
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 (creator_code:org_t)
2020-10-22
2020
English.
In: Scientific Reports. - : Springer Nature. - 2045-2322. ; 10:1
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  • Journal article (peer-reviewed)
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  • Malignant gliomas are primary brain tumours with an infiltrative growth pattern, often with contrast enhancement on magnetic resonance imaging (MRI). However, it is well known that tumour infiltration extends beyond the visible contrast enhancement. The aim of this study was to investigate if there is contrast enhancement not detected visually in the peritumoral oedema of malignant gliomas by using relaxometry with synthetic MRI. 25 patients who had brain tumours with a radiological appearance of malignant glioma were prospectively included. A quantitative MR-sequence measuring longitudinal relaxation (R-1), transverse relaxation (R-2) and proton density (PD), was added to the standard MRI protocol before surgery. Five patients were excluded, and in 20 patients, synthetic MR images were created from the quantitative scans. Manual regions of interest (ROIs) outlined the visibly contrast-enhancing border of the tumours and the peritumoral area. Contrast enhancement was quantified by subtraction of native images from post GD-images, creating an R-1-difference-map. The quantitative R-1-difference-maps showed significant contrast enhancement in the peritumoral area (0.047) compared to normal appearing white matter (0.032), p = 0.048. Relaxometry detects contrast enhancement in the peritumoral area of malignant gliomas. This could represent infiltrative tumour growth.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)

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