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A single-cell type transcriptomics map of human tissues

Karlsson, Max (author)
KTH,Systembiologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Dept Prot Sci, Sci Life Lab, Stockholm, Sweden.
Zhang, Cheng (author)
KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,KTH Royal Inst Technol, Dept Prot Sci, Sci Life Lab, Stockholm, Sweden.
Méar, Loren (author)
Uppsala universitet,Klinisk och experimentell patologi
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Zhong, Wen (author)
KTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab
Digre, Andreas (author)
Uppsala universitet,Klinisk och experimentell patologi
Katona, Borbala (author)
Uppsala universitet,Klinisk och experimentell patologi
Sjöstedt, Evelina (author)
Karolinska Inst, Dept Neurosci, Stockholm, Sweden.
Butler, Lynn M. (author)
Karolinska Institutet,KTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik,KTH Royal Inst Technol, Dept Prot Sci, Sci Life Lab, Stockholm, Sweden.;Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.;Karolinska Univ Hosp, Karolinska Univ Lab, Clin Chem, Stockholm, Sweden.;Arctic Univ Norway, Dept Clin Med, Tromso, Norway.
Odeberg, Jacob, Professor, 1963- (author)
KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap,KTH Royal Inst Technol, Dept Prot Sci, Sci Life Lab, Stockholm, Sweden.;Arctic Univ Norway, Dept Clin Med, Tromso, Norway.
Dusart, Philip (author)
KTH,Cellulär och klinisk proteomik,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Dept Prot Sci, Sci Life Lab, Stockholm, Sweden.;Arctic Univ Norway, Dept Clin Med, Tromso, Norway.
Edfors, Fredrik (author)
KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,KTH Royal Inst Technol, Dept Prot Sci, Sci Life Lab, Stockholm, Sweden.
Oksvold, Per (author)
KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,KTH Royal Inst Technol, Dept Prot Sci, Sci Life Lab, Stockholm, Sweden.
von Feilitzen, Kalle (author)
KTH,Systembiologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Dept Prot Sci, Sci Life Lab, Stockholm, Sweden.
Zwahlen, Martin (author)
KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,KTH Royal Inst Technol, Dept Prot Sci, Sci Life Lab, Stockholm, Sweden.
Arif, Muhammad (author)
KTH,Systembiologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Dept Prot Sci, Sci Life Lab, Stockholm, Sweden.
Altay, Özlem (author)
KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,KTH Royal Inst Technol, Dept Prot Sci, Sci Life Lab, Stockholm, Sweden.
Li, Xiangyu (author)
KTH,Systembiologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Dept Prot Sci, Sci Life Lab, Stockholm, Sweden.
Ozcan, Mehmet (author)
KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap,KTH Royal Inst Technol, Dept Prot Sci, Sci Life Lab, Stockholm, Sweden.
Mardinoglu, Adil (author)
KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,KTH Royal Inst Technol, Dept Prot Sci, Sci Life Lab, Stockholm, Sweden.
Fagerberg, Linn (author)
KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,KTH Royal Inst Technol, Dept Prot Sci, Sci Life Lab, Stockholm, Sweden.
Mulder, Jan (author)
Karolinska Institutet
Luo, Yonglun (author)
BGI Qingdao, BGI Shenzhen, Lars Bolund Inst Regenerat Med & Qingdao Europe A, Qingdao, Peoples R China.;Aarhus Univ, Dept Biomed, Aarhus, Denmark.
Pontén, Fredrik (author)
Uppsala universitet,Klinisk och experimentell patologi
Uhlén, Mathias (author)
KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,KTH Royal Inst Technol, Dept Prot Sci, Sci Life Lab, Stockholm, Sweden.;Karolinska Inst, Dept Neurosci, Stockholm, Sweden.
Lindskog, Cecilia (author)
Uppsala universitet,Klinisk och experimentell patologi
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 (creator_code:org_t)
American Association for the Advancement of Science (AAAS), 2021
2021
English.
In: Science Advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 7:31
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Advances in molecular profiling have opened up the possibility to map the expression of genes in cells, tissues, and organs in the human body. Here, we combined single-cell transcriptomics analysis with spatial antibody-based protein profiling to create a high-resolution single-cell type map of human tissues. An open access atlas has been launched to allow researchers to explore the expression of human protein-coding genes in 192 individual cell type clusters. An expression specificity classification was performed to determine the number of genes elevated in each cell type, allowing comparisons with bulk transcriptomics data. The analysis highlights distinct expression clusters corresponding to cell types sharing similar functions, both within the same organs and between organs.

Subject headings

NATURVETENSKAP  -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

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