Experimental Characterization and Mathematical Modeling of the Adsorption of Proteins and Cells on Biomimetic Hydroxyapatite

Atif, Abdul-Raouf, 1996- (author): Uppsala universitet,Institutionen för materialvetenskap,EMBLA

Lacis, Ugis, 1988- (author): KTH,Teknisk mekanik,Linné Flow Center, FLOW,KTH Royal Inst Technol, FLOW Ctr, Dept Engn Mech, S-11428 Stockholm, Sweden.

Engqvist, Håkan, 1972- (author): Uppsala universitet,Tillämpad materialvetenskap

Tenje, Maria (author): Uppsala universitet,Institutionen för materialvetenskap,Science for Life Laboratory, SciLifeLab,EMBLA

Bagheri, Shervin, 1979- (author): KTH,Strömningsmekanik och Teknisk Akustik,Linné Flow Center, FLOW,KTH Royal Inst Technol, FLOW Ctr, Dept Engn Mech, S-11428 Stockholm, Sweden.

Mestres, Gemma, 1984- (author): Uppsala universitet,Institutionen för materialvetenskap,Science for Life Laboratory, SciLifeLab,EMBLA

(creator_code:org_t)

2021-12-22
2022
English.
In: ACS Omega. - : American Chemical Society (ACS). - 2470-1343. ; 7:1, s. 908-920

Related links:: https://doi.org/10.1...; show more...; https://pubs.acs.org...; https://uu.diva-port... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; https://urn.kb.se/re...; show less...

Abstract Subject headings

Biomaterial development is a long process consisting of multiple stages of design and evaluation within the context of both in vitro and in vivo testing. To streamline this process, mathematical and computational modeling displays potential as a tool for rapid biomaterial characterization, enabling the prediction of optimal physicochemical parameters. In this work, a Langmuir isotherm-based model was used to describe protein and cell adhesion on a biomimetic hydroxyapatite surface, both independently and in a one-way coupled system. The results indicated that increased protein surface coverage leads to improved cell adhesion and spread, with maximal protein coverage occurring within 48 h. In addition, the Langmuir model displayed a good fit with the experimental data. Overall, computational modeling is an exciting avenue that may lead to savings in terms of time and cost during the biomaterial development process.

By the author/editor: Atif, Abdul-Raou ...; Lacis, Ugis, 198 ...; Engqvist, Håkan, ...; Tenje, Maria; Bagheri, Shervin ...; Mestres, Gemma, ...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Biochemistry and ...

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