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A novel nanoparticle system targeting damaged mitochondria for the treatment of Parkinson's disease
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- Chen, Yue (author)
- Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China.
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- Zhang, Bosong (author)
- Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China.
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- Yu, Lina (author)
- Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China.
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- Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China Harbin Med Univ, Dept Neurol, Affiliated Hosp 1, Harbin 150080, Peoples R China. (creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
- In: Biomaterials Advances. - : Elsevier BV. - 2772-9516 .- 2772-9508. ; 138
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Mitochondrial damage is one of the primary causes of neuronal cell death in Parkinson's disease (PD). In PD patients, the mitochondrial damage can be repaired or irreversible. Therefore, mitochondrial damage repair becomes a promising strategy for PD treatment. In this research, hyaluronic acid nanoparticles (HA-NPs) of different molecular weights are used to protect the mitochondria and salvage the mild and limited damage in mitochondria. The HA-NPs with 2190 k Dalton (kDa) HA can improve the mitochondrial function of SH-SY5Y cells and PTEN induced putative kinase 1 (PINK1) knockout mouse embryo fibroblast (MEF) cells. In cases of irreversible damage, NPs with ubiquitin specific peptidase 30 (USP30) siRNA are used to promote mitophagy. Meanwhile, by adding PINK1 antibodies, the NPs can selectively target the irreversibly damaged mitochondria, preventing the excessive clearance of healthy mitochondria.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Parkinson's disease
- Hyaluronic acid
- PINK1 antibody
- USP30 siRNA
- Nanoparticles
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Chen, Yue
- Zhang, Bosong
- Yu, Lina
- Zhang, Jinyu
- Zhao, Yufang
- Yao, Lifen
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- Yan, Hongji
- Tian, Weiming
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- About the subject
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- NATURAL SCIENCES
- NATURAL SCIENCES
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- Karolinska Institutet
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