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Sökning: id:"swepub:oai:DiVA.org:kth-322611" > The neuropeptide la...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007977naa a2200649 4500
001oai:DiVA.org:kth-322611
003SwePub
008221223s2022 | |||||||||||000 ||eng|
009oai:DiVA.org:liu-189628
009oai:prod.swepub.kib.ki.se:151307286
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3226112 URI
0247 a https://doi.org/10.1073/pnas.21231461192 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1896282 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1513072862 URI
040 a (SwePub)kthd (SwePub)liud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Zhong, Wenu Linköpings universitet,KTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden.;Linköping Univ, Dept Biomed & Clin Sci BKV, Sci Life Lab, S-58225 Linköping, Sweden.,Avdelningen för cellbiologi,Medicinska fakulteten,Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden;Science for Life Laboratory, Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden4 aut0 (Swepub:liu)wenzh16
2451 0a The neuropeptide landscape of human prefrontal cortex
264 c 2022-08-10
264 1b Proceedings of the National Academy of Sciences,c 2022
338 a print2 rdacarrier
500 a QC 20221223
500 a Funding agency:  National Genomics Infrastructure in Stockholm - Science for Life Laboratory; Knut and Alice Wallenberg Foundation; Swedish Research Council [2018-02753, 2020-02956]; SciLifeLab; Wallenberg Data Driven Life Science Program [KAW 2020.0239]; Hungarian Brain Research Program [2017-1.2.1-NKP-201700002]
520 a Human prefrontal cortex (hPFC) is a complex brain region involved in cognitive and emotional processes and several psychiatric disorders. Here, we present an overview of the distribution of the peptidergic systems in 17 subregions of hPFC and three reference cortices obtained by microdissection and based on RNA sequencing and RNA-scope methods integrated with published single-cell transcriptomics data. We detected expression of 60 neuropeptides and 60 neuropeptide receptors in at least one of the hPFC subregions. The results reveal that the peptidergic landscape in PFC consists of closely located and functionally different subregions with unique peptide/transmitter- related profiles. Neuropeptide-rich PFC subregions were identified, encompassing regions from anterior cingulate cortex/orbitofrontal gyrus. Furthermore, marked differences in gene expression exist between different PFC regions (>5-fold; cocaine and amphetamine-regulated transcript peptide) as well as between PFC regions and reference regions, for example, for somatostatin and several receptors. We suggest that the present approach allows definition of, still hypothetical, microcircuits exemplified by glutamatergic neurons expressing a peptide cotransmitter either as an agonist (hypocretin/orexin) or antagonist (galanin). Specific neuropeptide receptors have been identified as possible targets for neuronal afferents and, interestingly, peripheral blood-borne peptide hormones (leptin, adiponectin, gastric inhibitory peptide, glucagon-like peptides, and peptide YY). Together with other recent publications, our results support the view that neuropeptide systems may play an important role in hPFC and underpin the concept that neuropeptide signaling helps stabilize circuit connectivity and fine-tune/modulate PFC functions executed during health and disease.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653 a anterior cingulate cortex
653 a in situ hybridization
653 a RNA-seq
653 a classic neurotransmitter coexistence
7001 a Barde, Swapnaliu Karolinska Institutet4 aut
7001 a Mitsios, Nicholasu Karolinska Institutet4 aut
7001 a Adori, Csabau Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden.,Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden4 aut
7001 a Oksvold, Peru KTH,Science for Life Laboratory, SciLifeLab,Science for Life Laboratory, Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden4 aut0 (Swepub:kth)u1qey3lv
7001 a von Feilitzen, Kalleu KTH,Proteinteknologi,Science for Life Laboratory, SciLifeLab,Science for Life Laboratory, Department of Protein Science, KTH Royal Institute of Technology,Stockholm, Sweden4 aut0 (Swepub:kth)u1dbmi38
7001 a O'Learyd, Liamu McGill Univ, Dept Psychiat, Montreal, PQ, Canada.;Douglas Hosp, McGill Grp Suicide Studies, Montreal, PQ, Canada.,Department of Psychiatry, McGill University, Montreal, Canada; McGill Group for Suicide Studies, Douglas Hospital Research Centre, Montreal, Canada4 aut
7001 a Csiba, Laszlou Univ Debrecen, Dept Neurol, Fac Med, H-4032 Debrecen, Hungary.,Department of Neurology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary4 aut
7001 a Hortobagyi, Tiboru Univ Szeged, Inst Pathol, Fac Med, H-6720 Szeged, Hungary.,Institute of Pathology, Faculty of Medicine, University of Szeged, Hungary4 aut
7001 a Szocsics, Peteru Semmelweis Univ, Szentagothai Janos Doctoral Sch Neurosci, H-1085 Budapest, Hungary.;Eotvos Lorand Res Network ELKH, Inst Expt Med, Human Brain Res Lab, H-1052 Budapest, Hungary.,Szentágothai János Doctoral School of Neuroscience, Semmelweis University, 1085 Budapest, Hungary;Human Brain Research Laboratory, Institute of Experimental Medicine, Eötvös Loránd Research Network (ELKH), Budapest, Hungary4 aut
7001 a Mechawar, Naguibu McGill Univ, Dept Psychiat, Montreal, PQ, Canada.;Douglas Hosp, McGill Grp Suicide Studies, Montreal, PQ, Canada.,Department of Psychiatry, McGill University, Montreal, Canada;McGill Group for Suicide Studies, Douglas Hospital Research Centre, Montreal, QC H4H 1R3, Canada4 aut
7001 a Magloczky, Zsofiau Eotvos Lorand Res Network ELKH, Inst Expt Med, Human Brain Res Lab, H-1052 Budapest, Hungary.,Human Brain Research Laboratory, Institute of Experimental Medicine, Eötvös Loránd Research Network (ELKH), Budapest, Hungary4 aut
7001 a Renner, Evau Semmelweis Univ, Human Brain Tissue Bank, H-1085 Budapest, Hungary.,Human Brain Tissue Bank, Semmelweis University, Budapest, Hungary4 aut
7001 a Palkovits, Miklosu Semmelweis Univ, Human Brain Tissue Bank, H-1085 Budapest, Hungary.,Human Brain Tissue Bank, Semmelweis University, Budapest, Hungary4 aut
7001 a Uhlén, Mathiasu KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap,Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden,Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden;Science for Life Laboratory, Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden4 aut0 (Swepub:kth)u1dulvmw
7001 a Mulder, Janu Karolinska Institutet4 aut
7001 a Hokfelt, Tomasu Karolinska Institutet4 aut
7102 a KTHb Proteinvetenskap4 org
7730 t Proceedings of the National Academy of Sciences of the United States of Americad : Proceedings of the National Academy of Sciencesg 119:33q 119:33x 0027-8424x 1091-6490
8564 u https://doi.org/10.1073/pnas.2123146119y Fulltext
8564 u https://liu.diva-portal.org/smash/get/diva2:1707174/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-322611
8564 8u https://doi.org/10.1073/pnas.2123146119
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-189628
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:151307286

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