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Profiling spatiotem...
Profiling spatiotemporal gene expression of the developing human spinal cord and implications for ependymoma origin
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- Li, Xiaofei (author)
- Karolinska Institutet,Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden.
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- Andrusivova, Zaneta (author)
- KTH,Science for Life Laboratory, SciLifeLab,Genteknologi,KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden.
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- Czarnewski, Paulo (author)
- KTH,Science for Life Laboratory, SciLifeLab,Genteknologi,KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden.;Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Natl Bioinformat Infrastruct Sweden, Stockholm, Sweden.
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- Langseth, Christoffer Mattsson (author)
- Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Stockholm, Sweden.
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- Andersson, Alma (author)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden.;Genentech Inc, Dept Artificial Intelligence & Machine Learning, Res & Early Dev, South San Francisco, CA USA.
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- Liu, Yang (author)
- Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden.;Capital Med Univ, Beijing Tiantan Hosp, China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China.
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- Gyllborg, Daniel (author)
- Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Stockholm, Sweden.
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- Braun, Emelie (author)
- Karolinska Inst, Dept Med Biochem & Biophys, Div Mol Neurobiol, Stockholm, Sweden.
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- Larsson, Ludvig (author)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden.
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- Hu, Lijuan (author)
- Karolinska Inst, Dept Med Biochem & Biophys, Div Mol Neurobiol, Stockholm, Sweden.
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- Alekseenko, Zhanna (author)
- Karolinska Institutet,Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden.;Karolinska Inst, Dept Cell & Mol Biol, Stockholm, Sweden.
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- Lee, Hower (author)
- Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Stockholm, Sweden.
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- Avenel, Christophe (author)
- Uppsala universitet,Bildanalys och människa-datorinteraktion,Avdelningen Vi3,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Dept Informat Technol, Uppsala, Sweden.;SciLifeLab, BioImage Informat Facil, Sci Life Lab, Stockholm, Sweden.
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- Kallner, Helena Kopp (author)
- Karolinska Institutet,Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Stockholm, Sweden.;Danderyd Hosp, Dept Obstet & Gynecol, Danderyd, Sweden.
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- Akesson, Elisabet (author)
- Karolinska Institutet,Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden.;Stockholms Sjukhem, R&D Unit, Stockholm, Sweden.
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- Adameyko, Igor (author)
- Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.;Med Univ Vienna, Ctr Brain Res, Dept Neuroimmunol, Vienna, Austria.
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- Nilsson, Mats (author)
- Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Stockholm, Sweden.
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- Linnarsson, Sten (author)
- Karolinska Institutet,Karolinska Inst, Dept Med Biochem & Biophys, Div Mol Neurobiol, Stockholm, Sweden.
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- Lundeberg, Joakim (author)
- KTH,Science for Life Laboratory, SciLifeLab,Genteknologi,KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden.
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- Sundstrom, Erik (author)
- Karolinska Institutet,Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden.
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Karolinska Institutet Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden (creator_code:org_t)
- Springer Nature, 2023
- 2023
- English.
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In: Nature Neuroscience. - : Springer Nature. - 1097-6256 .- 1546-1726. ; 26:5, s. 891-901
- Related links:
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Subject headings
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- The authors created a comprehensive developmental cell atlas for spatiotemporal gene expression of the human spinal cord, revealed species-specific regulation during development and used the atlas to infer novel markers for pediatric ependymomas. The spatiotemporal regulation of cell fate specification in the human developing spinal cord remains largely unknown. In this study, by performing integrated analysis of single-cell and spatial multi-omics data, we used 16 prenatal human samples to create a comprehensive developmental cell atlas of the spinal cord during post-conceptional weeks 5-12. This revealed how the cell fate commitment of neural progenitor cells and their spatial positioning are spatiotemporally regulated by specific gene sets. We identified unique events in human spinal cord development relative to rodents, including earlier quiescence of active neural stem cells, differential regulation of cell differentiation and distinct spatiotemporal genetic regulation of cell fate choices. In addition, by integrating our atlas with pediatric ependymomas data, we identified specific molecular signatures and lineage-specific genes of cancer stem cells during progression. Thus, we delineate spatiotemporal genetic regulation of human spinal cord development and leverage these data to gain disease insight.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Li, Xiaofei
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Andrusivova, Zan ...
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Czarnewski, Paul ...
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Langseth, Christ ...
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Andersson, Alma
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Liu, Yang
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show more...
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Gyllborg, Daniel
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Braun, Emelie
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Larsson, Ludvig
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Hu, Lijuan
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Alekseenko, Zhan ...
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Lee, Hower
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Avenel, Christop ...
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Kallner, Helena ...
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Akesson, Elisabe ...
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Adameyko, Igor
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Nilsson, Mats
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Linnarsson, Sten
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Lundeberg, Joaki ...
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Sundstrom, Erik
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Nature Neuroscie ...
- By the university
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Royal Institute of Technology
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Karolinska Institutet
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Uppsala University