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Microfluidic Device...
Microfluidic Device for Patient-Centric Multiplexed Assays with Readout in Centralized Laboratories
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- Hauser, Janosch (författare)
- KTH,Mikro- och nanosystemteknik
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- Dale, Matilda (författare)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab
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- Beck, Olof (författare)
- Karolinska Institutet, Clinical Neuroscience, 17177 Stockholm, Sweden
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- Schwenk, Jochen M. (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik
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- Stemme, Göran, 1958- (författare)
- KTH,Mikro- och nanosystemteknik
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- Fredolini, Claudia (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik
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- Roxhed, Niclas (författare)
- KTH,Mikro- och nanosystemteknik,MedTechLabs, BioClinicum, Karolinska University Hospital, 17164 Solna, Sweden
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(creator_code:org_t)
- 2022-12-22
- 2023
- Engelska.
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Ingår i: Analytical Chemistry. - : American Chemical Society (ACS). - 0003-2700 .- 1520-6882. ; 95:2, s. 1350-1358
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Patient-centric sampling strategies, where the patient performs self-sampling and ships the sample to a centralized laboratory for readout, are on the verge of widespread adaptation. However, the key to a successful patient-centric workflow is user-friendliness, with few noncritical user interactions, and simple, ideally biohazard-free shipment. Here, we present a capillary-driven microfluidic device designed to perform the critical biomarker capturing step of a multiplexed immunoassay at the time of sample collection. On-chip sample drying enables biohazard-free shipment and allows us to make use of advanced analytics of specialized laboratories that offer the needed analytical sensitivity, reliability, and affordability. Using C-Reactive Protein, MCP1, S100B, IGFBP1, and IL6 as model blood biomarkers, we demonstrate the multiplexing capability and applicability of the device to a patient-centric workflow. The presented quantification of a biomarker panel opens up new possibilities for e-doctor and e-health applications.
Ämnesord
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
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