SwePub
Sök i LIBRIS databas

  Extended search

id:"swepub:oai:DiVA.org:kth-331449"
 

Search: id:"swepub:oai:DiVA.org:kth-331449" > The acute effect of...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

The acute effect of different NAD+ precursors included in the combined metabolic activators

Li, Xiangyu (author)
KTH,Systembiologi,Science for Life Laboratory, SciLifeLab,Bash Biotech Inc, 600 West Broadway, Suite 700, San Diego, CA 92101, USA, 600 West Broadway, Suite 700; Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden; Guangzhou Laboratory, Guangzhou 510005, China,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)
Yang, Hong (author)
KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)
Jin, Han (author)
KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH),Göteborgs universitet,University of Gothenburg
show more...
Turkez, Hasan (author)
Department of Medical Biology, Faculty of Medicine, Ataturk University, Erzurum, Turkey,Atatürk Üniversitesi,Atatürk University
Ozturk, Gurkan (author)
Research Institute for Health Sciences and Technologies (SABITA), International School of Medicine, Istanbul Medipol University, 34810 Istanbul, Turkey,Istanbul Medipol Universitesi
Doganay, Hamdi Levent (author)
Gastroenterology and Hepatology Unit, VM Pendik Medicalpark Teaching Hospital, Istanbul, Turkey; Department of Internal Medicine, Bahcesehir University (BAU), Istanbul, Turkey
Zhang, Cheng (author)
KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)
Nielsen, Jens B, 1962 (author)
Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden; BioInnovation Institute, Ole Maaloees Vej 3, DK2200, Copenhagen, Denmark, Ole Maaløes Vej 3,BioInnovation Institute (BII),Chalmers tekniska högskola,Chalmers University of Technology
Uhlén, Mathias (author)
KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)
Borén, Jan (author)
Department of Molecular and Clinical Medicine, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden
Mardinoglu, Adil (author)
KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, United Kingdom,King's College London,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)
show less...
 (creator_code:org_t)
Elsevier BV, 2023
2023
English.
In: Free Radical Biology & Medicine. - : Elsevier BV. - 0891-5849 .- 1873-4596. ; 205, s. 77-89
Related links:
https://urn.kb.se/re...
show more...
https://doi.org/10.1...
https://research.cha...
show less...
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • NAD+ and glutathione precursors are currently used as metabolic modulators for improving the metabolic conditions associated with various human diseases, including non-alcoholic fatty liver disease, neurodegenerative diseases, mitochondrial myopathy, and age-induced diabetes. Here, we performed a one-day double blinded, placebo-controlled human clinical study to assess the safety and acute effects of six different Combined Metabolic Activators (CMAs) with 1 g of different NAD+ precursors based on global metabolomics analysis. Our integrative analysis showed that the NAD+ salvage pathway is the main source for boosting the NAD+ levels with the administration of CMAs without NAD+ precursors. We observed that incorporation of nicotinamide (Nam) in the CMAs can boost the NAD+ products, followed by niacin (NA), nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), but not flush free niacin (FFN). In addition, the NA administration led to a flushing reaction, accompanied by decreased phospholipids and increased bilirubin and bilirubin derivatives, which could be potentially risky. In conclusion, this study provided a plasma metabolomic landscape of different CMA formulations, and proposed that CMAs with Nam, NMN as well as NR can be administered for boosting NAD+ levels to improve altered metabolic conditions.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
NATURVETENSKAP  -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

Keyword

Carnitine
Cysteine
Metabolomics
NAD precursors
Serine
Systems medicine

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view