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Spatial transcriptomics of B cell and T cell receptors reveals lymphocyte clonal dynamics

Engblom, Camilla (author)
Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Thrane, Kim (author)
KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
Lin, Qirong (author)
Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
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Andersson, Alma (author)
KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
Toosi, Hosein (author)
KTH,Beräkningsvetenskap och beräkningsteknik (CST),Science for Life Laboratory, SciLifeLab
Chen, Xinsong (author)
Karolinska Institutet
Steiner, Embla (author)
Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Lu, Chang (author)
Heidelberg University, Faculty of Medicine and Heidelberg University Hospital, Institute for Computational Biomedicine, Heidelberg, Germany.
Mantovani, Giulia (author)
Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Hagemann-Jensen, Michael (author)
Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Saarenpää, Sami (author)
KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
Jangard, Mattias (author)
ENT Unit, Sophiahemmet University Research Laboratory and Sophiahemmet Hospital, Stockholm, Sweden.
Saez-Rodriguez, Julio (author)
Heidelberg University, Faculty of Medicine and Heidelberg University Hospital, Institute for Computational Biomedicine, Heidelberg, Germany.
Michaëlsson, Jakob (author)
Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
Hartman, Johan (author)
Karolinska Institutet
Lagergren, Jens (author)
KTH,Beräkningsvetenskap och beräkningsteknik (CST),Science for Life Laboratory, SciLifeLab
Mold, Jeff E. (author)
Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Lundeberg, Joakim (author)
KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
Frisén, Jonas (author)
Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
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Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden Genteknologi (creator_code:org_t)
American Association for the Advancement of Science (AAAS), 2023
2023
English.
In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 382:6675, s. 8486-
Related links:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • The spatial distribution of lymphocyte clones within tissues is critical to their development, selection, and expansion. We have developed spatial transcriptomics of variable, diversity, and joining (VDJ) sequences (Spatial VDJ), a method that maps B cell and T cell receptor sequences in human tissue sections. Spatial VDJ captures lymphocyte clones that match canonical B and T cell distributions and amplifies clonal sequences confirmed by orthogonal methods. We found spatial congruency between paired receptor chains, developed a computational framework to predict receptor pairs, and linked the expansion of distinct B cell clones to different tumor-associated gene expression programs. Spatial VDJ delineates B cell clonal diversity and lineage trajectories within their anatomical niche. Thus, Spatial VDJ captures lymphocyte spatial clonal architecture across tissues, providing a platform to harness clonal sequences for therapy.

Subject headings

NATURVETENSKAP  -- Biologi -- Utvecklingsbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Developmental Biology (hsv//eng)

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