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Modelling large sca...
Modelling large scale artery haemodynamics from the heart to the eye in response to simulated microgravity
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- Caddy, Harrison T. (författare)
- Vascular Engineering Laboratory, Harry Perkins Institute of Medical Research, Queen Elizabeth II Medical Centre, Nedlands, Australia and the UWA Centre for Medical Research, The University of Western Australia, Perth, WA, Australia; School of Human Sciences (Exercise and Sport Sciences), The University of Western Australia, Perth, WA, Australia
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- Kelsey, Lachlan J. (författare)
- Vascular Engineering Laboratory, Harry Perkins Institute of Medical Research, Queen Elizabeth II Medical Centre, Nedlands, Australia and the UWA Centre for Medical Research, The University of Western Australia, Perth, WA, Australia; School of Engineering, The University of Western Australia, Perth, WA, Australia
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- Parker, Louis P. (författare)
- KTH,Teknisk mekanik,Linné Flow Center, FLOW
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- Green, Daniel J. (författare)
- School of Human Sciences (Exercise and Sport Sciences), The University of Western Australia, Perth, WA, Australia
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- Doyle, Barry J. (författare)
- Vascular Engineering Laboratory, Harry Perkins Institute of Medical Research, Queen Elizabeth II Medical Centre, Nedlands, Australia and the UWA Centre for Medical Research, The University of Western Australia, Perth, WA, Australia; School of Engineering, The University of Western Australia, Perth, WA, Australia
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(creator_code:org_t)
- Nature Research, 2024
- 2024
- Engelska.
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Ingår i: npj Microgravity. - : Nature Research. - 2373-8065. ; 10:1
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- We investigated variations in haemodynamics in response to simulated microgravity across a semi-subject-specific three-dimensional (3D) continuous arterial network connecting the heart to the eye using computational fluid dynamics (CFD) simulations. Using this model we simulated pulsatile blood flow in an upright Earth gravity case and a simulated microgravity case. Under simulated microgravity, regional time-averaged wall shear stress (TAWSS) increased and oscillatory shear index (OSI) decreased in upper body arteries, whilst the opposite was observed in the lower body. Between cases, uniform changes in TAWSS and OSI were found in the retina across diameters. This work demonstrates that 3D CFD simulations can be performed across continuously connected networks of small and large arteries. Simulated results exhibited similarities to low dimensional spaceflight simulations and measured data—specifically that blood flow and shear stress decrease towards the lower limbs and increase towards the cerebrovasculature and eyes in response to simulated microgravity, relative to an upright position in Earth gravity.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Maskinteknik -- Strömningsmekanik och akustik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Mechanical Engineering -- Fluid Mechanics and Acoustics (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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