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Anticorrosive evalu...
Anticorrosive evaluation of an environmentally benign chromone-thiazole hybrid with excellent anticancer activity
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- Kumar Sharma, Manish (author)
- Department of Chemistry, Deenbandhu Chhotu Ram University of Science & Technology, Murthal, Sonipat 131039, Haryana, India, Murthal, Haryana
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- Parashar, Sonia (author)
- Shri Baba Mastnath Institute of Pharmaceutical Sciences and Research, Asthal Bohar, Rohtak 124001, Haryana, India, Haryana
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- Sharma, Deepak (author)
- Department of Chemistry, Deenbandhu Chhotu Ram University of Science & Technology, Murthal, Sonipat 131039, Haryana, India, Murthal, Haryana
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- Jakhar, Kranti (author)
- Department of Chemistry, Deenbandhu Chhotu Ram University of Science & Technology, Murthal, Sonipat 131039, Haryana, India, Murthal, Haryana
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- Sihmar, Ashish (author)
- Department of Chemistry, Maharshi Dayanand University, Rohtak 124001, Haryana, India, Haryana
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- Kumar, Suresh (author)
- Department of Chemistry, Chaudhary Devi Lal University, Sirsa 125055, Haryana, India, Haryana
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- Jhaa, Gaurav (author)
- Department of Chemistry, Chemical Information Sciences Laboratory, Pondicherry University, Puducherry 605014, India, Puducherry
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- Dahiya, Hariom (author)
- Department of Chemistry, Maharshi Dayanand University, Rohtak 124001, Haryana, India, Haryana
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- Bhardwaj, Anand (author)
- KTH,Strukturer
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- Lal, Kashmiri (author)
- Department of Chemistry, Guru Jambheshwar University of Science & Technology, Hisar 125001, Haryana, India, Haryana
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- Om, Hari (author)
- Department of Chemistry, Deenbandhu Chhotu Ram University of Science & Technology, Murthal, Sonipat 131039, Haryana, India, Murthal, Haryana
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(creator_code:org_t)
- Elsevier B.V. 2024
- 2024
- English.
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In: Journal of Molecular Liquids. - : Elsevier B.V.. - 0167-7322 .- 1873-3166. ; 405
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The research article comprehensively presents salient applications of an environment friendly chromone-thiazole hybrid (CTH) as a potential anticancer molecule and as an organic inhibitor against mild steel (MS) corrosion. The SRB assay used for antiproliferative screening gives excellent IC50 (10.8 μM) against MDA-MB-231 (breast cancer) cell line. Further, CTH has excellent inhibition efficacy (∼97 % at 400 ppm) against MS corrosion in 1 M HCl. The in vitro results of anticancer and anticorrosive evaluation are in good agreement with the computational studies, which include docking, ADME, DFT, MD simulation, and toxicity prediction.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- ADME
- Anticancer
- Chromone-benzothiazole hybrid
- Corrosion inhibition
- Docking studies
- MD simulation
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kumar Sharma, Ma ...
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Parashar, Sonia
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Sharma, Deepak
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Jakhar, Kranti
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Sihmar, Ashish
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Kumar, Suresh
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show more...
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Jhaa, Gaurav
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Dahiya, Hariom
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Bhardwaj, Anand
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Lal, Kashmiri
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Om, Hari
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Journal of Molec ...
- By the university
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Royal Institute of Technology