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Sökning: id:"swepub:oai:DiVA.org:kth-52551" > Pdlim2 is a novel a...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003483naa a2200469 4500
001oai:DiVA.org:kth-52551
003SwePub
008111219s2011 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:123623950
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-525512 URI
0247 a https://doi.org/10.1038/ki.2011.2312 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1236239502 URI
040 a (SwePub)kthd (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Sistani, Laleh4 aut
2451 0a Pdlim2 is a novel actin-regulating protein of podocyte foot processes
264 1b Elsevier BV,c 2011
338 a print2 rdacarrier
500 a QC 20111219
520 a The slit diaphragm and the apical and basal membrane domains of podocytes are connected to each other by an actin-based cytoskeleton critical to the maintenance of the glomerular filtration barrier. In an effort to discover novel regulatory proteins of the podocyte foot process, we identified and characterized pdlim2, a member of the actin-associated LIM protein subfamily of cytosolic proteins typified by an N-terminal PDZ domain and a C-terminal LIM domain. In the kidney, the pdlim2 protein is highly specific for the glomerulus and podocyte foot processes as shown by RT-PCR, western blotting, immunofluorescence, and immunoelectron microscopy. In cultured podocytes, pdlim2 was associated with stress fibers and cortical actin. Pdlim2 seems to regulate actin dynamics in podocytes since stress fibers were stabilized in its presence. Mechanistically, pdlim2 interacts with two actin-associated podocyte proteins, alpha-actinin-4 and angiomotin-like-1, as shown by immunoprecipitation and yeast two-hybrid analyses. By semi-quantitative immunoelectron microscopy, there was a reduced expression of pdlim2 in podocytes of patients with minimal change nephrotic syndrome and membranous nephropathy, whereas its expression was unchanged in patients with focal segmental glomerulosclerosis. Hence, pdlim2 is a novel actin-regulating protein of podocyte foot processes that may have a role in the pathogenesis of glomerular diseases.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
653 a cytoskeleton
653 a podocyte
653 a proteinuria
7001 a Dunér, Fredriku Karolinska Institutet4 aut
7001 a Udumala, Sunil4 aut
7001 a Hultenby, Kjellu Karolinska Institutet4 aut
7001 a Uhlén, Mathiasu KTH,Proteomik4 aut0 (Swepub:kth)u1dulvmw
7001 a Betsholtz, Christeru Karolinska Institutet4 aut
7001 a Tryggvason, Karlu Karolinska Institutet4 aut
7001 a Wernerson, Annikau Karolinska Institutet4 aut
7001 a Patrakka, Jaakkou Karolinska Institutet4 aut
7102 a Karolinska Institutetb Proteomik4 org
7730 t Kidney Internationald : Elsevier BVg 80:10, s. 1045-1054q 80:10<1045-1054x 0085-2538x 1523-1755
8564 u http://www.kidney-international.org/article/S0085253815549508/pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-52551
8564 8u https://doi.org/10.1038/ki.2011.231
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:123623950

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