Health-Related Quality of Life in Patients with Advanced Nonsquamous Non-Small-Cell Lung Cancer Receiving Bevacizumab or Bevacizumab-Plus-Pemetrexed Maintenance Therapy in AVAPERL (MO22089)

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Health-Related Quality of Life in Patients with Advanced Nonsquamous Non-Small-Cell Lung Cancer Receiving Bevacizumab or Bevacizumab-Plus-Pemetrexed Maintenance Therapy in AVAPERL (MO22089)

Rittmeyer, Achim (author): Lungenfachklin Immenhausen, Germany

Gorbunova, Vera (author): NN Blokhin Cancer Research Centre Russia, Russia

Vikström, Anders (author): Östergötlands Läns Landsting,Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet,Lungmedicinska kliniken US

Scherpereel, Arnaud (author): CHRU Lille, France

Kim, Joo-Hang (author): Yonsei University, South Korea

Ahn, Myung-Ju (author): Sungkyunkwan University, South Korea

Chella, Antonio (author): University of Pisa, Italy

Chouaid, Christos (author): Hop St Antoine, France

Campbell, Alicyn K. (author): Genentech Inc, CA USA

Barlesi, Fabrice (author): Aix Marseille University, France

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Lippincott, Williams and Wilkins, 2013
2013
English.
In: Journal of Thoracic Oncology. - : Lippincott, Williams and Wilkins. - 1556-0864 .- 1556-1380. ; 8:11, s. 1409-1416

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Introduction: In the phase III AVAPERL trial, patients with advanced nonsquamous non-small-cell lung cancer receiving bevacizumab-plus-pemetrexed maintenance after first-line induction had a significant progression-free survival benefit relative to those treated with single-agent bevacizumab maintenance but with an increase in grade 3 adverse events. Here, we compare health-related quality of life (HRQOL) between AVAPERL maintenance arms. less thanbrgreater than less thanbrgreater thanMethods: Patient-reported outcomes were collected at designated intervals from preinduction to final visits. HRQOL was assessed using the self-administered European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 and the Quality of Life Lung Cancer-Specific Module 13. Differences in scores of 10 points or more between arms were above the minimum important difference threshold and considered clinically meaningful. less thanbrgreater than less thanbrgreater thanResults: During induction, patient-reported coughing symptoms improved slightly, whereas fatigue and appetite loss scores worsened relative to preinduction baseline. During maintenance, changes in mean global health status and the majority of Quality of Life Questionnaire Core 30 and Quality of Life Lung Cancer-Specific Module 13 subscale scores did not differ between trial arms by the minimum important difference defining clinically meaningful (better or worse) patient-reported outcomes. Exceptions were patient-reported role functional status, fatigue symptoms and appetite loss symptoms (favoring bevacizumab), and pain in arm or shoulder symptoms (favoring bevacizumab-plus-pemetrexed maintenance), which differed by clinically meaningful amounts at more than one maintenance assessment. less thanbrgreater than less thanbrgreater thanConclusions: In AVAPERL, HRQOL remained relatively stable throughout maintenance and was generally similar in both arms. Despite an increase in adverse event rates, the addition of pemetrexed to bevacizumab maintenance resulted in similar stabilization of disease symptoms with improved efficacy outcomes.

Keyword

Patient-reported outcomes
Non-small-cell lung cancer
Bevacizumab
Pemetrexed
AVAPERL
Maintenance
MEDICINE
MEDICIN

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By the author/editor: Rittmeyer, Achim; Gorbunova, Vera; Vikström, Anders; Scherpereel, Arn ...; Kim, Joo-Hang; Ahn, Myung-Ju; show more...; Chella, Antonio; Chouaid, Christo ...; Campbell, Alicyn ...; Barlesi, Fabrice; show less...

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By the university: Linköping University

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