Imaging of the guinea pig cochlea following round window gadolinium application

Bjelke, Börje (author): Örebro University Hospital, Sweden,Department of Clinical Neuroscience, Karolinska Institutet, 171 76 Stockholm, Sweden

Counter, Allen (author): Department of Clinical Neuroscience, Karolinska Institutet, 171 76 Stockholm, Sweden

Klason, Tomas (author): Department of Clinical Neuroscience, Karolinska Institutet, 171 76 Stockholm, Sweden

Borg, Erik (author): Ahlsen Research Institute, Örebro University Hospital, 701 85 Örebro, Sweden

(creator_code:org_t)

Wolters Kluwer, 2004
2004
English.
In: NeuroReport. - : Wolters Kluwer. - 0959-4965 .- 1473-558X. ; 15:12, s. 1927-1930

Related links:: http://ovidsp.tx.ovi...; show more...; https://urn.kb.se/re...; https://urn.kb.se/re...; http://kipublication...; https://doi.org/10.1...; show less...

Abstract Subject headings

Precise, non-invasive determination of the aetiology and site of pathology of inner ear disorders is difficult. The aim of this study was to describe an alternative method for inner ear visualization, based on local application of the paramagnetic contrast agent gadolinium. Using a 4.7 T MRI scanner, high contrast images of all four cochlear turns were obtained 3.5 h after placing gadolinium on the round window membrane. Gadolinium cleared from the cochlea within 96 h. Auditory brainstem response measurements performed on a separate group of animals showed no significant threshold shifts after the application, indicating that gadolinium is non-toxic to the guinea pig cochlea.

By the author/editor: Duan, Maoli; Bjelke, Börje; Fridberger, Ande ...; Counter, Allen; Klason, Tomas; Skjönsberg, Åsa; show more...; Herrlin, Petra; Borg, Erik; Laurell, Göran; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

By the university: Linköping University; Umeå University; Karolinska Institutet

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