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Advances in the man...
Advances in the management of hereditary medullary thyroid cancer
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- Machens, A. (författare)
- Martin-Luther-University Halle-Wittenberg, Halle, Saale, Germany
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- Ukkat, J. (författare)
- Martin-Luther-University Halle-Wittenberg, Halle, Saale, Germany
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- Brauckhoff, M. (författare)
- Martin-Luther-University Halle-Wittenberg, Halle, Saale, Germany
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- Gimm, Oliver (författare)
- Martin-Luther-University Halle-Wittenberg, Halle, Saale, Germany
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- Dralle, H. (författare)
- Martin-Luther-University Halle-Wittenberg, Halle, Saale, Germany
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(creator_code:org_t)
- Wiley-Blackwell, 2005
- 2005
- Engelska.
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Ingår i: Journal of Internal Medicine. - : Wiley-Blackwell. - 0954-6820 .- 1365-2796. ; 257:1, s. 50-59
- Relaterad länk:
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- This work draws on recent advances during the era of codon-oriented prophylactic surgery for hereditary medullary thyroid cancer (MTC). Milestones included identification of RET (REarranged during Transfection) as the susceptibility gene, introduction of prophylactic surgery on evidence of a RET germline mutation, revelation of genotype-phenotype correlations within the MEN 2 spectrum and demonstration of age-related progression of MTC. Novel surgical techniques, notably systemic microdissection and compartment-oriented surgery, have greatly enhanced surgical cure. Uncovering molecular pathways from RET genotype to MEN 2 phenotype should provide treatment options for RET mutation carriers whose MTC currently is too advanced for cure.
Nyckelord
- age-related progression
- calcitonin
- monitoring
- medullary thyroid cancer
- MEN type 2
- nodal metastasis
- RET proto-oncogene.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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