id:"swepub:oai:DiVA.org:liu-101833"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03924naa a2200349 4500 | |
| 001 | oai:DiVA.org:liu-101833 | |
| 003 | SwePub | |
| 008 | 131124s2011 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1018332 URI |
| 024 | 7 | a https://doi.org/10.1097/ALN.0b013e318231fc112 DOI |
| 040 | a (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Mahmoud, Saifeldinu Penn State College of Medicine, Hershey, PA, USA4 aut |
| 245 | 1 0 | a Pharmacological consequence of the A118G μ opioid receptor polymorphism on morphine- and fentanyl-mediated modulation of Ca²⁺ channels in humanized mouse sensory neurons |
| 264 | 1 | b Lippincott Williams & Wilkins,c 2011 |
| 338 | a print2 rdacarrier | |
| 520 | a BACKGROUND: The most common functional single nucleotide polymorphism of the human OPRM1 gene, A118G, has been shown to be associated with interindividual differences in opioid analgesic requirements, particularly with morphine, in patients with acute postoperative pain. The purpose of this study was to examine whether this polymorphism would modulate the morphine and fentanyl pharmacological profile of sensory neurons isolated from a humanized mouse model homozygous for either the 118A or 118G allele.METHODS: The coupling of wild-type and mutant μ opioid receptors to voltage-gated Ca channels after exposure to either ligand was examined by employing the whole cell variant of the patch-clamp technique in acutely dissociated trigeminal ganglion neurons. Morphine-mediated antinociception was measured in mice carrying either the 118AA or 118GG allele.RESULTS: The biophysical parameters (cell size, current density, and peak current amplitude potential) measured from both groups of sensory neurons were not significantly different. In 118GG neurons, morphine was approximately fivefold less potent and 26% less efficacious than that observed in 118AA neurons. On the other hand, the potency and efficacy of fentanyl were similar for both groups of neurons. Morphine-mediated analgesia in 118GG mice was significantly reduced compared with the 118AA mice.CONCLUSIONS: This study provides evidence to suggest that the diminished clinical effect observed with morphine in 118G carriers results from an alteration of the receptor's pharmacology in sensory neurons. In addition, the impaired analgesic response with morphine may explain why carriers of this receptor variant have an increased susceptibility to become addicted to opioids. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 700 | 1 | a Thorsell, Annikau National Institute on Alcohol Abuse and Alcoholism, NIH; Bethesda, MD, USA4 aut0 (Swepub:liu)annth96 |
| 700 | 1 | a Sommer, Wolfgang H.u University of Heidelberg, Germany4 aut |
| 700 | 1 | a Heilig, Markusu National Institute on Alcohol Abuse and Alcoholism, NIH; Bethesda, MD, USA4 aut0 (Swepub:liu)marhe41 |
| 700 | 1 | a Holgate, Joan K.u Ernest Gallo Clinic and Research Center, University of California-San Francisco, Emeryville, CA, USA4 aut |
| 700 | 1 | a Bartlett, Selena E.u Ernest Gallo Clinic and Research Center, University of California-San Francisco, Emeryville, CA, USA4 aut |
| 700 | 1 | a Ruiz-Velasco, Victoru Penn State College of Medicine, Hershey, PA, USA4 aut |
| 710 | 2 | a Penn State College of Medicine, Hershey, PA, USAb National Institute on Alcohol Abuse and Alcoholism, NIH; Bethesda, MD, USA4 org |
| 773 | 0 | t Anesthesiologyd : Lippincott Williams & Wilkinsg 115:5, s. 1054-1062q 115:5<1054-1062x 0003-3022x 1528-1175 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-101833 |
| 856 | 4 8 | u https://doi.org/10.1097/ALN.0b013e318231fc11 |
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