Multiple endocrine neoplasia type 1 (MEN1): loss of one MEN1 allele in tumors and monohormonal endocrine cell clusters but not in islet hyperplasia of the pancreas.

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: id:"swepub:oai:DiVA.org:liu-101870" > Multiple endocrine ...

1 av 1
Föregående post
Nästa post
Till träfflistan

Multiple endocrine neoplasia type 1 (MEN1) : loss of one MEN1 allele in tumors and monohormonal endocrine cell clusters but not in islet hyperplasia of the pancreas.

Perren, Aurel (författare): Department of Pathology, Institute of Surgical Pathology, University Hospital, CH-8091 Zürich, Switzerland / Institute of Pathology, Technische Universitaet Muenchen, D-81675 Munich, Germany

Anlauf, Martin (författare): Department of Pathology, University of Kiel, D-24105 Kiel, Germany

Henopp, Tobias (författare): Department of Pathology, University of Kiel, D-24105 Kiel, Germany

visa fler...

Rudolph, Thomas (författare): Department of Pathology, Institute of Surgical Pathology, University Hospital, CH-8091 Zürich, Switzerland

Schmitt, Anja (författare): Department of Pathology, Institute of Surgical Pathology, University Hospital, CH-8091 Zürich, Switzerland

Raffel, Andreas (författare): Department of General, Visceral, and Pediatric Surgery, University of Düsseldorf, D-40225 Düsseldorf, Germany

Gimm, Oliver (författare): Department of General, Visceral, and Vascular Surgery, University of Halle, D-06120 Halle, Germany

Weihe, Eberhard (författare): Departments of Molecular Neuroscience and Anatomy and Cell Biology, University of Marburg, D-35037 Marburg, Germany

Knoefel, Wolfram T (författare): Department of General, Visceral, and Pediatric Surgery, University of Düsseldorf, D-40225 Düsseldorf, Germany

Dralle, Henning (författare): Department of General, Visceral, and Vascular Surger, University of Halle, D-06120 Halle, Germany

Heitz, Philipp U (författare): Department of Pathology, Institute of Surgical Pathology, University Hospital, CH-8091 Zürich, Switzerland

Komminoth, Paul (författare): Institute of Pathology, Stadtspital Triemli, CH-8063 Zurich, Switzerland

Klöppel, Günter (författare): Department of Pathology, University of Kiel, D-24105 Kiel, Germany

visa färre...

(creator_code:org_t)

The Endocrine Society, 2007
2007
Engelska.
Ingår i: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 92:3, s. 1118-28

Relaterad länk:: https://academic.oup...; visa fler...; https://urn.kb.se/re...; https://doi.org/10.1...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

CONTEXT: The occurrence of multiple small pancreatic endocrine tumors in patients suffering from multiple endocrine neoplasia type 1 (MEN1) represents a unique possibility to study early neoplasms and their potential precursor lesions. To date, it is unknown whether small islet-like endocrine cell clusters found in MEN1 patients are neoplastic or rather hyperplastic. It is also unclear whether microadenomas develop from islets.DESIGN: We hypothesized that monohormonal endocrine cell clusters observed in MEN1 patients are small neoplasms with loss of heterozygosity of the MEN1 locus. Using a technique combining fluorescence in situ hybridization of the MEN1 locus and the centromeric region of chromosome 11q with hormone immunostaining, we examined resection specimens from four MEN1 patients. We focused our investigations on the following: 1) typical microadenomas; 2) monohormonal endocrine cell clusters; 3) endocrine and exocrine structures entrapped in microadenomas; and 4) morphologically normal islets.RESULTS: Loss of one MEN1 allele was found in all 27 microadenomas and 19 of 20 (95%) monohormonal endocrine cell clusters. By contrast, it was absent in islets and ductal or acinar structures. Our results indicate that monohormonal endocrine cell clusters represent a minute form of microadenomas.CONCLUSION: The frequent presence of single nonneoplastic insulin cells in microadenomas and the occurrence of microadenomas in islets suggest an islet origin of microadenomas. Islet hyperplasia does not seem to be an obligatory stage in pancreatic MEN1-associated tumor development.

Hitta via bibliotek

Journal of Clinical Endocrinology and Metabolism (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

1 av 1
Föregående post
Nästa post
Till träfflistan

Hitta mer i SwePub

Av författaren/redakt...: Perren, Aurel; Anlauf, Martin; Henopp, Tobias; Rudolph, Thomas; Schmitt, Anja; Raffel, Andreas; visa fler...; Gimm, Oliver; Weihe, Eberhard; Knoefel, Wolfram ...; Dralle, Henning; Heitz, Philipp U; Komminoth, Paul; Klöppel, Günter; visa färre...

Artiklar i publikationen: Journal of Clini ...

Av lärosätet: Linköpings universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se

Multiple endocrine neoplasia type 1 (MEN1) : loss of one MEN1 allele in tumors and monohormonal endocrine cell clusters but not in islet hyperplasia of the pancreas.

Publikations- och innehållstyp

Hitta via bibliotek

Till lärosätets databas

Hitta mer i SwePub

Sök utanför SwePub