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One-step synthesis ...
One-step synthesis of water-dispersible ultra-small Fe3O4 nanoparticles as contrast agents for T-1 and T-2 magnetic resonance imaging
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- Wang, Guannan (författare)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska högskolan,Liaoning Medical University, Jinzhou, China
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- Zhang, Xuanjun (författare)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten
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- Skallberg, Andreas (författare)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten
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- Liu, Yaxu (författare)
- Liaoning Medical University, Peoples R China Liaoning Medical University, Peoples R China
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- Hu, Zhang-Jun (författare)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten
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- Mei, Xifan (författare)
- Liaoning Medical University, Peoples R China
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- Uvdal, Kajsa (författare)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten
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(creator_code:org_t)
- Royal Society of Chemistry, 2014
- 2014
- Engelska.
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Ingår i: Nanoscale. - : Royal Society of Chemistry. - 2040-3364 .- 2040-3372. ; 6:5, s. 2953-2963
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Uniform, highly water-dispersible and ultra-small Fe3O4 nanoparticles were synthesized via a modified one-step coprecipitation approach. The prepared Fe3O4 nanoparticles not only show good magnetic properties, long-term stability in a biological environment, but also exhibit good biocompatibility in cell viability and hemolysis assay. Due to the ultra-small sized and highly water-dispersibility, they exhibit excellent relaxivity properties, the 1.7 nm sized Fe3O4 nanoparticles reveal a low r(2)/r(1) ratio of 2.03 (r(1) = 8.20 mM(-1) s(-1), r(2) = 16.67 mM(-1) s(-1)); and the 2.2 nm sized Fe3O4 nanoparticles also appear to have a low r2/r1 ratio of 4.65 (r(1) = 6.15 mM(-1) s(-1), r(2) = 28.62 mM(-1) s(-1)). This demonstrates that the proposed ultra-small Fe3O4 nanoparticles have great potential as a new type of T-1 magnetic resonance imaging contrast agents. Especially, the 2.2 nm sized Fe3O4 nanoparticles, have a competitive r(1) value and r(2) value compared to commercial contrasting agents such as Gd-DTPA (r(1) = 4.8 mM(-1) s(-1)), and SHU-555C (r(2) = 69 mM(-1) s(-1)). In vitro and in vivo imaging experiments, show that the 2.2 nm sized Fe3O4 nanoparticles exhibit great contrast enhancement, long-term circulation, and low toxicity, which enable these ultrasmall sized Fe3O4 nanoparticles to be promising as T-1 and T-2 dual contrast agents in clinical settings.
Ämnesord
- NATURVETENSKAP -- Fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences (hsv//eng)
Nyckelord
- TECHNOLOGY
- TEKNIKVETENSKAP
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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