Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity

Gottsäter, Mikael (author): Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Lund University, Malmö, Sweden

Länne, Toste (author): Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Thorax-kärlkliniken i Östergötland

Nilsson, P M (author): Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Lund University, Malmö, Sweden

(creator_code:org_t)

2014-01-02
2014
English.
In: Journal of Human Hypertension. - : Nature Publishing Group. - 0950-9240 .- 1476-5527. ; 28:7, s. 456-460

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Abstract Subject headings

Arterial stiffness is influenced by advancing age and vascular disease and is an independent risk factor for cardiovascular events and death. Using ultrasound measurements, arterial stiffness in a specific arterial segment can be assessed. The aim of this observational study was to explore the prospective and cross- sectional associations between arterial stiffness measured by ultrasound locally in the abdominal aorta and cardiovascular risk factors/markers including insulin resistance measured by the homeostatic model assessment- insulin resistance (HOMA- IR), lipids and abdominal obesity. This study includes 335 subjects from Malmo ", Sweden, examined in 1991- 1994 and again at follow- up in 1998- 2000 (mean age 64 years, 42% men). Ultrasound measurement of the abdominal aorta was performed at follow- up investigation. In the female subgroup, there was a positive association between HOMA-IR at baseline and abdominal aortic stiffness at follow-up (beta = 0.18, P 0.03) and a negative association between high-density lipoprotein and aortic stiffness (beta = 0.23, P 0.005), independently of classical cardiovascular risk factors. These associations were not found among men. The results suggest a greater or different role of impaired glucose metabolism in the pathophysiology of arterial stiffness in women than in men.

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

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