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Overexpression of M...
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Jönsson, SimonLinköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet
(author)
Overexpression of MMP-9 and Its Inhibitors in Blood Mononuclear Cells after Myocardial Infarction - Is It Associated with Depressive Symptomatology?
- Article/chapterEnglish2014
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2014-08-25
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Public Library of Science,2014
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electronicrdacarrier
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LIBRIS-ID:oai:DiVA.org:liu-110970
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-110970URI
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https://doi.org/10.1371/journal.pone.0105572DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Funding Agencies|Swedish Research Council [521-2011-3847]; Swedish Heart-Lung Foundation [20120608]
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Background: Matrix metalloproteinase (MMP)-9 may play a central role in the development and progression of atherosclerosis. Emerging evidence also indicates an association between MMP-9 and depressive symptomatology. Here, we investigated whether expression of MMP-9 and its inhibitors in blood mononuclear cells and plasma were related to depressive symptoms in patients with a recent myocardial infarction (MI). Methods and Results: Blood sampling was performed between 6 and 18 months after MI in 57 patients. Forty-one clinically healthy subjects were included as controls. Gene expression of MMP-9 and its main tissue inhibitors TIMP-1 and -2 were analyzed in freshly isolated or cultured blood mononuclear cells. Corresponding protein levels were assessed in cell supernatants and plasma. In post-MI patients, mRNA levels of MMP-9 and TIMP-1 and -2 were significantly higher than in controls while protein levels in cell supernatants and plasma did not differ between groups. The Center for Epidemiological Studies - Depression (CES-D) scale was used to assess depressive symptomatology. Repeated assessments during the first 18 months after MI showed significantly higher CES-D scores in patients compared with controls. However, there were no relationships between depressive mood and any of the measurements of MMP-9 or TIMPs. Conclusion: Our findings indicate that overexpression of MMP-9 and TIMPs in blood mononuclear cells and elevated depressive symptoms represent two unrelated phenomena after MI.
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Lundberg, AnnaLinköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet(Swepub:liu)annli40
(author)
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Jonasson, LenaÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet,Kardiologiska kliniken US(Swepub:liu)lenjo59
(author)
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Linköpings universitetAvdelningen för kardiovaskulär medicin
(creator_code:org_t)
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In:PLOS ONE: Public Library of Science9:8, s. e105572-1932-6203
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