SwePub
Sök i LIBRIS databas

  Extended search

id:"swepub:oai:DiVA.org:liu-115820"
 

Search: id:"swepub:oai:DiVA.org:liu-115820" > Role of PD-1 co-inh...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Role of PD-1 co-inhibitory pathway in HIV infection and potential therapeutic options

Velu, Vijayakumar (author)
Emory University, GA 30322 USA; Yerkes National Primate Research Centre, GA 30329 USA
Dyavar Shetty, Ravi (author)
Emory University, GA 30322 USA; Yerkes National Primate Research Centre, GA 30329 USA; University of Nebraska Medical Centre, NE USA
Larsson, Marie (author)
Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet
show more...
Shankar, Esaki M. (author)
University of Malaya, Malaysia; University of Malaya, Malaysia; University of Malaya, Malaysia
show less...
 (creator_code:org_t)
2015-02-08
2015
English.
In: Retrovirology. - : BioMed Central. - 1742-4690. ; 12:14
  • Research review (peer-reviewed)
Abstract Subject headings
Close  
  • Virus-specific CD8(+) T cells play an important role in controlling viral infections including human immunodeficiency virus (HIV) infection. However, during chronic HIV infection, virus-specific CD8(+) T cells undergo functional exhaustion, lose effector functions and fail to control viral infection. HIV-specific CD8(+) T cells expressing high levels of co-inhibitory molecule programmed death-1 (PD-1) during the chronic infection and are characterized by lower proliferation, cytokine production, and cytotoxic abilities. Although, antiretroviral therapy has resulted in dramatic decline in HIV replication, there is no effective treatment currently available to eradicate viral reservoirs or restore virus-specific T or B-cell functions thatmay complement ART in order to eliminate the virus. In recent years, studies in mice and non-human primate models of HIV infection demonstrated the functional exhaustion of virus-specific T and B cells could be reversed by blockade of interaction between PD-1 and its cognate ligands (PD-L1 and PD-L2). In this review, we discuss recent advances in our understanding of PD-1 pathway in HIV/ SIV infection and discuss the beneficial effects of PD-1 blockade during chronic HIV/SIV infection and its potential role as immunotherapy for HIV/AIDS.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Keyword

HIV disease; PD-1 blockade; PD-1 pathway; SIV infection; T-cell dysfunction; B-cell dysfunction; PD-L1 and PD-L2

Publication and Content Type

ref (subject category)
for (subject category)

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Find more in SwePub

By the author/editor
Velu, Vijayakuma ...
Dyavar Shetty, R ...
Larsson, Marie
Shankar, Esaki M ...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
Articles in the publication
Retrovirology
By the university
Linköping University

Search outside SwePub

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view