id:"swepub:oai:DiVA.org:liu-117854"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04260naa a2200361 4500 | |
| 001 | oai:DiVA.org:liu-117854 | |
| 003 | SwePub | |
| 008 | 150511s2015 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1178542 URI |
| 040 | a (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Flejmer, Anna M.u Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US4 aut0 (Swepub:liu)annfl57 |
| 245 | 1 0 | a Analytical Anisotropic Algorithm versus Pencil Beam Convolution for treatment planning of breast cancer: implications for target coverage and radiation burden of normal tissue |
| 264 | 1 | b International Institute of Anticancer Research,c 2015 |
| 338 | a print2 rdacarrier | |
| 520 | a Aim: The present study aimed to investigate the implications of using the analytical anisotropic algorithm (AAA) for calculation of target coverage and radiation burden of normal tissues. Most model parameters, recommendations and planning guidelines associated with a certain outcome are from the era of pencil beam convolution (PBC) calculations on relatively simple assumptions of energy transport in media. Their relevance for AAA calculations that predict more realistic dose distributions needs to be evaluated. Patients and Methods: Forty patients with left-sided breast cancer receiving 3D conformal radiation therapy were planned using PBC with a standard protocol with 50 Gy in 25 fractions according to existing re-commendations. The plans were subsequently recalculated with the AAA and relevant dose parameters were determined and compared to their PBC equivalents. Results: The majority of the AAA-based plans had a significantly worse coverage of the planning target volume and also a higher maximum dose in hotspots near sensitive structures, suggesting that these criteria could be relaxed for AAA-calculated plans. Furthermore, the AAA predicts higher volumes of the ipsilateral lung will receive doses below 25 Gy and smaller volume doses above 25 Gy. These results indicate that lung tolerance criteria might also have to be relaxed for AAA planning in order to maintain the level of normal tissue toxicity. The AAA also predicts lower doses to the heart, thus indicating that this organ might be more sensitive to radiation than thought from PBC-based calculations. Conclusion: The AAA should be preferred over the PBC algorithm for breast cancer radiotherapy as it gives more realistic dose distributions. Guidelines for plan acceptance might have to be re-evaluated to account for differences in dose predictions in order to maintain the current levels of control and complication rates. The results also suggest an increased radiosensitivity of the heart, thus indicating that a revision of the current models for cardiovascular complications may be needed. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 653 | a breast radiotherapy | |
| 653 | a dose calculation algorithm | |
| 653 | a analytical anisotropic algorithm | |
| 653 | a pencil beam convolution | |
| 653 | a planning guidelines | |
| 700 | 1 | a Dohlmar, Fridau Linköpings universitet,Medicinska fakulteten,Avdelningen för radiologiska vetenskaper,Region Östergötland, Radiofysikavdelningen US4 aut0 (Swepub:liu)frias94 |
| 700 | 1 | a Nilsson, Matsu Futurum - Academy for Health and Care, Jönköping4 aut |
| 700 | 1 | a Stenmarker, Margarethau Futurum - Academy for Health and Care, Jönköping4 aut |
| 700 | 1 | a Dasu, Alexandruu Linköpings universitet,Östergötlands Läns Landsting,Radiofysikavdelningen US,Medicinska fakulteten,Avdelningen för radiologiska vetenskaper4 aut0 (Swepub:liu)aleda92 |
| 710 | 2 | a Linköpings universitetb Avdelningen för kliniska vetenskaper4 org |
| 773 | 0 | t Anticancer Researchd : International Institute of Anticancer Researchg 35:5, s. 2841-2848q 35:5<2841-2848x 0250-7005x 1791-7530 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-117854 |
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