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The complement syst...
The complement system and toll-like receptors as integrated players in the pathophysiology of atherosclerosis
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- Hovland, Anders (author)
- Nordland Hospital, Norway; University of Tromso, Norway
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- Jonasson, Lena (author)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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- Garred, Peter (author)
- Copenhagen University Hospital, Denmark
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- Yndestad, Arne (author)
- National Hospital Norway, Norway; National Hospital Norway, Norway; University of Oslo, Norway
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- Aukrust, Pal (author)
- National Hospital Norway, Norway; National Hospital Norway, Norway; University of Oslo, Norway
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- Lappegard, Knut T. (author)
- Nordland Hospital, Norway; University of Tromso, Norway
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- Espevik, Terje (author)
- Norwegian University of Science and Technology, Norway; Department Cancer Research and Molecular Med, Norway
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- Mollnes, Tom E. (author)
- University of Tromso, Norway; University of Oslo, Norway; Norwegian University of Science and Technology, Norway; Department Cancer Research and Molecular Med, Norway; Nordland Hospital, Norway; National Hospital Norway, Norway; University of Oslo, Norway; University of Tromso, Norway
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(creator_code:org_t)
- ELSEVIER IRELAND LTD, 2015
- 2015
- English.
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In: Atherosclerosis. - : ELSEVIER IRELAND LTD. - 0021-9150 .- 1879-1484. ; 241:2, s. 480-494
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Abstract
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- Despite recent medical advances, atherosclerosis is a global burden accounting for numerous deaths and hospital admissions. Immune-mediated inflammation is a major component of the atherosclerotic process, but earlier research focus on adaptive immunity has gradually switched towards the role of innate immunity. The complement system and toll-like receptors (TLRs), and the crosstalk between them, may be of particular interest both with respect to pathogenesis and as therapeutic targets in atherosclerosis. Animal studies indicate that inhibition of C3a and C5a reduces atherosclerosis. In humans modified LDL-cholesterol activate complement and TLRs leading to downstream inflammation, and histopathological studies indicate that the innate immune system is present in atherosclerotic lesions. Moreover, clinical studies have demonstrated that both complement and TLRs are upregulated in atherosclerotic diseases, although interventional trials have this far been disappointing. However, based on recent research showing an intimate interplay between complement and TLRs we propose a model in which combined inhibition of both complement and TLRs may represent a potent anti-inflammatory therapeutic approach to reduce atherosclerosis. (C) 2015 The Authors. Published by Elsevier Ireland Ltd.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- The complement system; Toll-like receptors; Atherosclerosis; Inflammation
Publication and Content Type
- ref (subject category)
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