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Operator training simulation for integrating cultivation and homogenisation in protein production
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- Gerlach, Inga (author)
- Linköpings universitet,Teknisk biologi,Tekniska fakulteten,Department of Environmental- and Bio-Technology, Hochschule Bremen University of Applied Sciences Bremen, Bremen, Germany
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- Mandenius, Carl-Fredrik (author)
- Linköpings universitet,Teknisk biologi,Tekniska fakulteten
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- Hass, Volker C. (author)
- Faculty of Medical and Life Sciences, Hochschule Furtwangen University of Applied Sciences Furtwangen, Germany
- (creator_code:org_t)
- Elsevier, 2015
- 2015
- English.
- In: Biotechnology Reports. - : Elsevier. - 2215-017X. ; 6, s. 91-99
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Operating training simulators (OTS) are virtual simulation tools used for training of process operators in industry in performing procedures and running processes. Based on structured mathematical models of the unit operations of a bioprocess an OTS can train a process operator by visualising changing conditions during the process, allow testing operator actions, testing controller settings, experience unexpected technical problems and getting practice in using prescribed standard procedures for a plant. This work shows the design of an OTS where two sequential steps of a recombinant protein production process, a fed-batch cultivation and a high-pressure homogenisation, are integrated. The OTS was evaluated on a user test group and showed that the OTS promoted and developed their understanding of the process, their capability to identify parameters influencing process efficiency and the skills of operating it.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik -- Bioprocessteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology -- Bioprocess Technology (hsv//eng)
Keyword
- Training simulator
- Recombinant protein production
- Cultivation
- Homogenisation
- Integrated process
Publication and Content Type
- ref (subject category)
- art (subject category)
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