A series of Zn(II) terpyridine complexes with enhanced two-photon-excited fluorescence for in vitro and in vivo bioimaging

Zhang, Qiong (author): Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten,Anhui University, Peoples R China

Hu, Zhang-Jun (author): Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten

Brommesson, Caroline (author): Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten

Tian, Yupeng (author): Anhui University, Peoples R China; Nanjing University, Peoples R China

Uvdal, Kajsa (author): Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten

(creator_code:org_t)

2015
2015
English.
In: Journal of materials chemistry. B. - : ROYAL SOC CHEMISTRY. - 2050-750X .- 2050-7518. ; 3:36, s. 7213-7221

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; show less...

Abstract Subject headings

It is still a challenge to obtain two-photon excited fluorescent bioimaging probes with intense emission, high photo-stability and low cytotoxicity. In the present work, four Zn(II)-coordinated complexes (1-4) constructed from two novel D-A and D-p-A ligands (L-1 and L-2) are investigated both experimentally and theoretically, aiming to explore efficient two-photon probes for bioimaging. Molecular geometry optimization used for theoretical calculations is achieved using the crystallographic data. Notably, the results indicate that complexes 1 and 2 display enhanced two-photon absorption (2PA) cross sections compared to their corresponding D-A ligand (L1). Furthermore, it was found that complex 1 has the advantages of moderate 2PA cross section in the near-infrared region, longer fluorescence lifetime, higher quantum yield, good biocompatibility and enhanced two-photon excited fluorescence. Therefore, complex 1 is evaluated as a bioimaging probe for in vitro imaging of HepG2 cells, in which it is observed under a two-photon scanning microscope that complex 1 exhibits effective co-staining with endoplasmic reticulum (ER) and nuclear membrane; as well as for in vivo imaging of zebrafish larva, in which it is observed that complex 1 exhibits specificity in the intestinal system.

By the author/editor: Zhang, Qiong; Tian, Xiaohe; Hu, Zhang-Jun; Brommesson, Caro ...; Wu, Jieying; Zhou, Hongping; show more...; Li, Shengli; Yang, Jiaxiang; Sun, Zhaoqi; Tian, Yupeng; Uvdal, Kajsa; show less...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Chemical Science ...; and Physical Chemist ...

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