Respiratory gating for proton beam scanning versus photon 3D-CRT for breast cancer radiotherapy

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: id:"swepub:oai:DiVA.org:liu-123274" > Respiratory gating ...

1 of 1
Previous record
Next record
To hitlist

Respiratory gating for proton beam scanning versus photon 3D-CRT for breast cancer radiotherapy

Flejmer, Anna M. (author): Linköping University,Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Onkologiska kliniken US,Medicinska fakulteten,Linköping Univ, Dept Oncol, Linköping, Sweden; Linköping Univ, Dept Clin & Expt Med, Linköping, Sweden

Edvardsson, Anneli (author): Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden

Dohlmar, Frida (author): Linköping University,Linköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Region Östergötland, Radiofysikavdelningen US,Linköping Univ, Dept Radiat Phys, Linköping, Sweden; Linköping Univ, Dept Med & Hlth Sci, Linköping, Sweden

Josefsson, Dan (author): Linköping University,Linköpings universitet,Medicinska fakulteten,Avdelningen för radiologiska vetenskaper,Region Östergötland, Radiofysikavdelningen US,Linköping Univ, Dept Radiat Phys, Linköping, Sweden; Linköping Univ, Dept Med & Hlth Sci, Linköping, Sweden

Nilsson, Mats (author): Futurum - Academy for Health and Care, Jönköping, Sweden,Cty Council Jönköping Futurum, Acad Hlth & Care, Jönköping, Sweden,Jönköping County Council

Witt Nyström, Petra (author): Uppsala universitet,Enheten för onkologi,Uppsala University Hospital, Sweden

Dasu, Alexandru (author): Linköping University,Linköpings universitet,Medicinska fakulteten,Avdelningen för radiologiska vetenskaper,Region Östergötland, Radiofysikavdelningen US,Linköping Univ, Dept Radiat Phys, Linköping, Sweden; Linköping Univ, Dept Med & Hlth Sci, Linköping, Sweden

show less...

(creator_code:org_t)

2016
2016
English.
In: Acta Oncologica. - 0284-186X .- 1651-226X. ; 55:5, s. 577-583

Related links:: https://doi.org/10.3...; show more...; http://www.tandfonli...; http://dx.doi.org/10...; https://urn.kb.se/re...; https://doi.org/10.3...; https://urn.kb.se/re...; https://lup.lub.lu.s...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background Respiratory gating and proton therapy have both been proposed to reduce the cardiopulmonary burden in breast cancer radiotherapy. This study aims to investigate the additional benefit of proton radiotherapy for breast cancer with and without respiratory gating.Material and methods Twenty left-sided patients were planned on computed tomography (CT)-datasets acquired during enhanced inspiration gating (EIG) and free-breathing (FB), using photon three-dimensional conformal radiation therapy (3D-CRT) and scanned proton beams. Ten patients received treatment to the whole breast only (WBO) and 10 were treated to the breast and the regional lymph nodes (BRN). Dosimetric parameters characterizing the coverage of target volumes and the cardiopulmonary burden were compared using a paired, two-tailed Student’s t-test.Results Protons ensured comparable or better target coverage than photons in all patients during both EIG and FB. The heterogeneity index decreased from 12% with photons to about 5% with protons. The mean dose to the ipsilateral lung was reduced in BRN patients from 12 Gy to 7 Gy (RBE) in EIG and from 14 Gy to 6-7 Gy (RBE) in FB, while for WBO patients all values were about 5-6 Gy (RBE). The mean dose to heart decreased by a factor of four in WBO patients [from 1.1 Gy to 0.3 Gy (RBE) in EIG and from 2.1 Gy to 0.5 Gy (RBE) in FB] and 10 in BRN patients [from 2.1 Gy to 0.2 Gy (RBE) in EIG and from 3.4 Gy to 0.3 Gy (RBE) in FB]. Similarly, the mean and the near maximum dose to left anterior descending artery (LAD) were significantly lower (p<0.05) with protons in comparison with photons.Conclusion Proton spot scanning has a high potential to reduce the irradiation of organs at risk and other normal tissues for most patients, beyond what could be achieved with EIG and photon therapy. The largest dose sparing has been seen for BRN patients, both in terms of cardiopulmonary burden and integral dose.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

Acta Oncologica (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Flejmer, Anna M.; Edvardsson, Anne ...; Dohlmar, Frida; Josefsson, Dan; Nilsson, Mats; Witt Nyström, Pe ...; show more...; Dasu, Alexandru; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Radiology Nuclea ...

Articles in the publication: Acta Oncologica

By the university: Linköping University; Uppsala University; Lund University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se