Inflammatory and endothelial markers during the menstrual cycle

Lindahl, Tomas (author): Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten,Region Östergötland, Klinisk kemi,Department of Clinical and Experimental Medicine , Linköping University , Linköping

Bystrom, Birgitta (author): Karolinska Institute, Sweden,Department of Women's and Children's Health, Division of Obstetrics and Gynecology , Karolinska Institutet , Stockholm

Larsson, Anders (author): Uppsala universitet,Biokemisk struktur och funktion,Uppsala University, Sweden

(creator_code:org_t)

2016-03-10
2016
English.
In: Scandinavian Journal of Clinical and Laboratory Investigation. - : TAYLOR & FRANCIS LTD. - 0036-5513 .- 1502-7686. ; 76:3, s. 190-194

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Abstract Subject headings

Background The menstrual cycle exhibits a pattern of repeated inflammatory activity. The present study aims to evaluate inflammatory and endothelial markers during the two phases of a menstrual cycle. Methods The study cohort consisted of 102 women with regular menstrual cycles. Inflammatory and endothelial markers (interleukin-6 [IL-6], pentraxin-3 [PTX-3], hs-C reactive protein [hs-CRP], sE-selectin, sP-selectin, intracellular and vascular cell adhesion molecules [ICAM-1 and VCAM-1] and cathepsins L, B and S) were measured during the early follicular and the late luteal phase of a normal menstrual cycle. Results Pentraxin-3 (PTX-3) and hs-CRP were significantly higher during the follicular phase compared to the luteal phase (p < 0.001 respectively p = 0.025). The other inflammatory and endothelial markers, with the exception of cathepsin B, were higher, albeit not significantly, during the follicular phase. Conclusions Inflammatory activity, expressed mainly by members of the pentraxin family, is higher during the early follicular compared to the luteal phase. This could be associated to menstruation but the exact mechanisms behind this pattern are unclear and might involve the ovarian hormones or an effect on hepatocytes.

By the author/editor: Chaireti, Roza; Lindahl, Tomas; Bystrom, Birgitt ...; Bremme, Katarina; Larsson, Anders

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Obstetrics Gynae ...

By the university: Linköping University; Uppsala University; Karolinska Institutet

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