Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients.

Liu, Na (author): Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US,State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi’an, China

Cox, Thomas R. (author): Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark

Cui, Weiyingqi (author): Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US

Adell, Gunnar, 1953- (author): Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US

Holmlund, Birgitta, 1958- (author): Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US

Ping, Jie (author): Shanghai Center for Bioinformation Technology, Shanghai, China

Jarlsfelt, Ingvar (author): Department of Pathology, Ryhov Hospital, Jönköping, Sweden

Erler, Janine T. (author): Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark

Sun, Xiao-Feng, 1959- (author): Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US

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Abstract Subject headings

Emerging evidence has implicated a pivotal role for lysyl oxidase (LOX) in cancer progression and metastasis. Whilst the majority of work has focused on the extracellular matrix cross-linking role of LOX, the exact function of intracellular LOX localisation remains unclear. In this study, we analysed the LOX expression patterns in the nuclei of rectal cancer patient samples and determined the clinical significance of this expression. Nuclear LOX expression was significantly increased in patient lymph node metastases compared to their primary tumours. High nuclear LOX expression in tumours was correlated with a high rate of distant metastasis and increased recurrence. Multivariable analysis showed that high nuclear LOX expression was also correlated with poor overall survival and disease free survival. Furthermore, we are the first to identify LOX enzyme isoforms (50 kDa and 32 kDa) within the nucleus of colon cancer cell lines by confocal microscopy and Western blot. Our results show a powerful link between nuclear LOX expression in tumours and patient survival, and offer a promising prognostic biomarker for rectal cancer patients.

By the author/editor: Liu, Na; Cox, Thomas R.; Cui, Weiyingqi; Adell, Gunnar, 1 ...; Holmlund, Birgit ...; Ping, Jie; show more...; Jarlsfelt, Ingva ...; Erler, Janine T.; Sun, Xiao-Feng, ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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