id:"swepub:oai:DiVA.org:liu-143927"
Sökning: id:"swepub:oai:DiVA.org:liu-143927" > Sex-biased microRNA...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04079naa a2200421 4500 | |
| 001 | oai:DiVA.org:liu-143927 | |
| 003 | SwePub | |
| 008 | 171229s2017 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1439272 URI |
| 024 | 7 | a https://doi.org/10.1101/gr.225391.1172 DOI |
| 040 | a (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Warnefors, Mariau Heidelberg University of ZMBH, Germany4 aut |
| 245 | 1 0 | a Sex-biased microRNA expression in mammals and birds reveals underlying regulatory mechanisms and a role in dosage compensation |
| 264 | c 2017-10-27 | |
| 264 | 1 | b COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT,c 2017 |
| 338 | a electronic2 rdacarrier | |
| 500 | a Funding Agencies|European Research Council [615253]; Swiss National Science Foundation [146474] | |
| 520 | a Sexual dimorphism depends on sex-biased gene expression, but the contributions of microRNAs (miRNAs) have not been globally assessed. We therefore produced an extensive small RNA sequencing data set to analyze male and female miRNA expression profiles in mouse, opossum, and chicken. Our analyses uncovered numerous cases of somatic sex-biased miRNA expression, with the largest proportion found in the mouse heart and liver. Sex-biased expression is explained by miRNA-specific regulation, including sex-biased chromatin accessibility at promoters, rather than piggybacking of intronic miRNAs on sex-biased protein-coding genes. In mouse, but not opossum and chicken, sex bias is coordinated across tissues such that autosomal testis-biased miRNAs tend to be somatically male-biased, whereas autosomal ovary-biased miRNAs are female-biased, possibly due to broad hormonal control. In chicken, which has a Z/W sex chromosome system, expression output of genes on the Z Chromosome is expected to be male-biased, since there is no global dosage compensation mechanism that restores expression in ZW females after almost all genes on the W Chromosome decayed. Nevertheless, we found that the dominant liver miRNA, miR-122-5p, is Z-linked but expressed in an unbiased manner, due to the unusual retention of a W-linked copy. Another Z-linked miRNA, the male-biased miR-2954-3p, shows conserved preference for dosage-sensitive genes on the Z Chromosome, based on computational and experimental data from chicken and zebra finch, and acts to equalize male-to-female expression ratios of its targets. Unexpectedly, our findings thus establish miRNA regulation as a novel gene-specific dosage compensation mechanism. | |
| 650 | 7 | a NATURVETENSKAPx Biologix Genetik0 (SwePub)106092 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Genetics0 (SwePub)106092 hsv//eng |
| 700 | 1 | a Mossinger, Katharinau Heidelberg University of ZMBH, Germany4 aut |
| 700 | 1 | a Halbert, Jeanu University of Lausanne, Switzerland4 aut |
| 700 | 1 | a Studer, Taniau Heidelberg University of ZMBH, Germany4 aut |
| 700 | 1 | a VandeBerg, John L.u University of Texas Rio Grande Valley, TX 78520 USA4 aut |
| 700 | 1 | a Lindgren, Isau Linköpings universitet,Biologi,Tekniska fakulteten4 aut0 (Swepub:liu)isali45 |
| 700 | 1 | a Fallahshahroudi, Amiru Linköpings universitet,Biologi,Tekniska fakulteten4 aut0 (Swepub:liu)amifa49 |
| 700 | 1 | a Jensen, Peru Linköpings universitet,Biologi,Tekniska fakulteten4 aut0 (Swepub:liu)perje15 |
| 700 | 1 | a Kaessmann, Henriku Heidelberg University of ZMBH, Germany4 aut |
| 710 | 2 | a Heidelberg University of ZMBH, Germanyb University of Lausanne, Switzerland4 org |
| 773 | 0 | t Genome Researchd : COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPTg 27:12, s. 1961-1973q 27:12<1961-1973x 1088-9051x 1549-5469 |
| 856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:1169791/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u http://genome.cshlp.org/content/27/12/1961.full.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-143927 |
| 856 | 4 8 | u https://doi.org/10.1101/gr.225391.117 |
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