5-ALA fluorescence and laser Doppler flowmetry for guidance in a stereotactic brain tumor biopsy

Haj-Hosseini, Neda, 1980- (author): Linköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten,MINT

Richter, Johan, 1960- (author): Linköpings universitet,Institutionen för medicinsk teknik,Tekniska fakulteten,Region Östergötland, Neurokirurgiska kliniken US

Milos, Peter, 1969- (author): Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Neurokirurgiska kliniken US,MINT

Hallbeck, Martin, 1970- (author): Linköpings universitet,Avdelning för neurobiologi,Medicinska fakulteten,Region Östergötland, Klinisk patologi

Wårdell, Karin, 1959- (author): Linköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten,MINT

(creator_code:org_t)

Optical Society of America, 2018
2018
English.
In: Biomedical Optics Express. - : Optical Society of America. - 2156-7085. ; 9:5, s. 2284-2296

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Abstract Subject headings

A fiber optic probe was developed for guidance during stereotactic brain biopsy procedures to target tumor tissue and reduce the risk of hemorrhage. The probe was connected to a setup for the measurement of 5-aminolevulinic acid (5-ALA) induced fluorescence and microvascular blood flow. Along three stereotactic trajectories, fluorescence (n = 109) and laser Doppler flowmetry (LDF) (n = 144) measurements were done in millimeter increments. The recorded signals were compared to histopathology and radiology images. The median ratio of protoporphyrin IX (PpIX) fluorescence and autofluorescence (AF) in the tumor was considerably higher than the marginal zone (17.3 vs 0.9). The blood flow showed two high spots (3%) in total. The proposed setup allows simultaneous and real-time detection of tumor tissue and microvascular blood flow for tracking the vessels.

By the author/editor: Haj-Hosseini, Ne ...; Richter, Johan, ...; Milos, Peter, 19 ...; Hallbeck, Martin ...; Wårdell, Karin, ...

About the subject

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