Fixed Combination Antiemetic A literature review on prevention of chemotherapy-induced nausea and vomiting using netupitant/palonosetron

Funding Agencies|Helsinn Healthcare SA; Eisai; Helsinn
BACKGROUND: Prevention of chemotherapy-induced nausea and vomiting (CINV) can be improved with guideline-consistent use of antiemetics. However, adherence to antiemetic guidelines remains often insufficient. Therefore, new strategies that improve adherence are needed. OBJECTIVES: To review the latest antiemetic guideline recommendations and provide an update on the use of NEPA, a fixed combination antiemetic composed of the neurokinin-1 receptor antagonist (RA) netupitant and the 5-hydroxytryptamine-3 RA palonosetron (Akynzeo (R)). METHODS: Analysis of the literature was performed, including guidelines, published literature, congress data on NEPA, and relevant articles on CINV. FINDINGS: Nurses are in a unique position to promote guideline-consistent antiemetic prophylaxis and are central in the education of patients and caregivers. Thus, nurses continuous education on antiemetic treatments is key for the prevention and management of CINV. NEPA offers a simplified antiemetic therapy with the potential to increase guideline adherence.

Vidall, CherylAlcura UK Ltd, England (author)
Börjeson, SussanneLinköpings universitet,Avdelningen för omvårdnad,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US(Swepub:liu)susbo15 (author)
Jahn, PatrickUniv Hosp Halle, Germany (author)
Univ Kansas, KS 66205 USAAlcura UK Ltd, England (creator_code:org_t)

In:Clinical Journal of Oncology Nursing: ONCOLOGY NURSING SOC22:2, s. E52-E631092-10951538-067X

By the author/editor: Clark-Snow, Rebe ...; Vidall, Cheryl; Börjeson, Sussan ...; Jahn, Patrick

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Nursing

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