id:"swepub:oai:DiVA.org:liu-167731"
Search: id:"swepub:oai:DiVA.org:liu-167731" > Histological 3D rec...
- 1 of 1
- Previous record
- Next record
- To hitlist
Histological 3D reconstruction and in vivo lineage tracing of the human endometrium
-
- Tempest, Nicola (author)
- Liverpool Womens Hosp NHS Fdn Trust, England; Liverpool Hlth Partnership, England; Univ Liverpool, England
-
- Jansen, Marnix (author)
- UCL, England
-
- Baker, Ann-Marie (author)
- Queen Mary Univ London, England
- show more...
- show less...
- (creator_code:org_t)
- 2020-06-30
- 2020
- English.
- In: Journal of Pathology. - : WILEY. - 0022-3417 .- 1096-9896. ; 251:4, s. 440-451
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Regular menstrual shedding and repair of the endometrial functionalis is unique to humans and higher-order primates. The current consensus postulates endometrial glands to have a single-tubular architecture, where multi-potential stem cells reside in the blind-ending glandular-bases. Utilising fixed samples from patients, we have studied the three-dimensional (3D) micro-architecture of the human endometrium. We demonstrate that some non-branching, single, vertical functionalis glands originate from a complex horizontally interconnecting network of basalis glands. The existence of a multipotent endometrial epithelial stem cell capable of regenerating the entire complement of glandular lineages was demonstrated byin vivolineage tracing, using naturally occurring somatic mitochondrial DNA mutations as clonal markers. Vertical tracking of mutated clones showed that at least one stem-cell population resides in the basalis glands. These novel findings provide insight into the efficient and scar-less regenerative potential of the human endometrium. (c) 2020 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- 3D reconstruction; lineage tracing; endometrium; regeneration; stem cells
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Journal of Pathology (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Tempest, Nicola
- Jansen, Marnix
- Baker, Ann-Marie
- Hill, Christophe ...
- Hale, Mike
- Magee, Derek
- show more...
- Treanor, Darren
- Wright, Nicholas ...
- Hapangama, Dhara ...
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Cell and Molecul ...
- Articles in the publication
- Journal of Patho ...
- By the university
- Linköping University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
