Prognostic significance of interleukin-17A-producing colorectal tumour antigen-specific T cells

Keita, Åsa (author): Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten

(creator_code:org_t)

2021-03-05
2021
English.
In: British Journal of Cancer. - : SPRINGERNATURE. - 0007-0920 .- 1532-1827. ; 124:9, s. 1552-1555

Related links:: https://liu.diva-por... (primary) (Raw object); show more...; https://www.nature.c...; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Abstract Subject headings

Background The T cell cytokine profile is a key prognostic indicator of post-surgical outcome for colorectal cancer (CRC). Whilst T(H)1 (IFN-gamma(+)) cell-mediated responses generated in CRC are well documented and are associated with improved survival, antigen-specific T(H)17 (IL-17A(+)) responses have not been similarly measured. Methods We sought to determine the cytokine profile of circulating tumour antigen-(5T4/CEA) specific T cells of 34 CRC patients to address whether antigen-specific IL-17A responses were detectable and whether these were distinct to IFN-gamma responses. Results As with IFN-gamma-producing T cells, anti-5T4/CEA T(H)17 responses were detectable predominantly in early stage (TNM I/II) CRC patients. Moreover, whilst IL-17A was always produced in association with IFN-gamma, this release was mainly from two distinct T cell populations rather than by dual producing T cells. Patients mounting both tumour-specific T(H)1(+)/T(H)17(+) responses exhibited prolonged relapse-free survival. Conclusions Tumour antigen-specific T(H)17 responses play a beneficial role in preventing post-operative colorectal tumour recurrence.

By the author/editor: Thomson, Amanda; Bento, Diana F. ...; Scurr, Martin J.; Smart, Kathryn; Somerville, Mich ...; Keita, Åsa; show more...; Gallimore, Awen; Godkin, Andrew; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.