Population-based body-brain mapping links brain morphology with anthropometrics and body composition

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Population-based body-brain mapping links brain morphology with anthropometrics and body composition

Gurholt, Tiril P. (author): Oslo Univ Hosp, Norway; Univ Oslo, Norway

Kaufmann, Tobias (author): Oslo Univ Hosp, Norway; Univ Oslo, Norway; Univ Tubingen, Germany

Frei, Oleksandr (author): Oslo Univ Hosp, Norway; Univ Oslo, Norway

Alnaes, Dag (author): Oslo Univ Hosp, Norway; Univ Oslo, Norway

Haukvik, Unn K. (author): Oslo Univ Hosp, Norway; Univ Oslo, Norway

van der Meer, Dennis (author): Oslo Univ Hosp, Norway; Univ Oslo, Norway; Maastricht Univ, Netherlands

Moberget, Torgeir (author): Oslo Univ Hosp, Norway; Univ Oslo, Norway; Univ Oslo, Norway

OConnell, Kevin S. (author): Oslo Univ Hosp, Norway; Univ Oslo, Norway

Dahlqvist Leinhard, Olof, 1978- (author): Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,AMRA Med, Linkoping, Sweden

Linge, Jennifer (author): AMRA Med, Linkoping, Sweden

Simon, Rozalyn (author): Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,AMRA Med, Linkoping, Sweden

Smeland, Olav B. (author): Oslo Univ Hosp, Norway; Univ Oslo, Norway

Sonderby, Ida E. (author): Oslo Univ Hosp, Norway; Univ Oslo, Norway; Oslo Univ Hosp, Norway

Winterton, Adriano (author): Oslo Univ Hosp, Norway; Univ Oslo, Norway

Steen, Nils Eiel (author): Oslo Univ Hosp, Norway; Univ Oslo, Norway

Westlye, Lars T. (author): Oslo Univ Hosp, Norway; Univ Oslo, Norway; Univ Oslo, Norway

Andreassen, Ole A. (author): Oslo Univ Hosp, Norway; Univ Oslo, Norway

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2021-05-18
2021
English.
In: Translational Psychiatry. - : Springer Nature. - 2158-3188. ; 11:1

Related links:: https://liu.diva-por... (primary) (Raw object); show more...; https://www.nature.c...; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

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Abstract Subject headings

Understanding complex body-brain processes and the interplay between adipose tissue and brain health is important for understanding comorbidity between psychiatric and cardiometabolic disorders. We investigated associations between brain structure and anthropometric and body composition measures using brain magnetic resonance imaging (MRI; n=24,728) and body MRI (n=4973) of generally healthy participants in the UK Biobank. We derived regional and global measures of brain morphometry using FreeSurfer and tested their association with (i) anthropometric measures, and (ii) adipose and muscle tissue measured from body MRI. We identified several significant associations with small effect sizes. Anthropometric measures showed negative, nonlinear, associations with cerebellar/cortical gray matter, and brain stem structures, and positive associations with ventricular volumes. Subcortical structures exhibited mixed effect directionality, with strongest positive association for accumbens. Adipose tissue measures, including liver fat and muscle fat infiltration, were negatively associated with cortical/cerebellum structures, while total thigh muscle volume was positively associated with brain stem and accumbens. Regional investigations of cortical area, thickness, and volume indicated widespread and largely negative associations with anthropometric and adipose tissue measures, with an opposite pattern for thigh muscle volume. Self-reported diabetes, hypertension, or hypercholesterolemia were associated with brain structure. The findings provide new insight into physiological body-brain associations suggestive of shared mechanisms between cardiometabolic risk factors and brain health. Whereas the causality needs to be determined, the observed patterns of body-brain relationships provide a foundation for understanding the underlying mechanisms linking psychiatric disorders with obesity and cardiovascular disease, with potential for the development of new prevention strategies.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)

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By the author/editor: Gurholt, Tiril P ...; Kaufmann, Tobias; Frei, Oleksandr; Alnaes, Dag; Haukvik, Unn K.; van der Meer, De ...; show more...; Moberget, Torgei ...; OConnell, Kevin ...; Dahlqvist Leinha ...; Linge, Jennifer; Simon, Rozalyn; Smeland, Olav B.; Sonderby, Ida E.; Winterton, Adria ...; Steen, Nils Eiel; Westlye, Lars T.; Andreassen, Ole ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

Articles in the publication: Translational Ps ...

By the university: Linköping University

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