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SARS-CoV-2 rapid an...
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Nordgren, JohanLinköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten
(författare)
SARS-CoV-2 rapid antigen test: High sensitivity to detect infectious virus
- Artikel/kapitelEngelska2021
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ELSEVIER,2021
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Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-177416
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-177416URI
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https://doi.org/10.1016/j.jcv.2021.104846DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:146893540URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Funding Agencies|Region Ostergotland [30320005]
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Background: The COVID-19 pandemic has highlighted the need for rapid, cost effective and easy-to-use diagnostic tools for SARS-CoV-2 infections that can be used in point of care settings to limit disease transmission. Objective: We evaluated two rapid antigen immunochromatographic tests, Abbott PanbioTM COVID-19 Ag Rapid Test (Panbio) and Zhejiang Orient Gene/Healgen Biotech Coronavirus Ag rapid test cassette (Orient gene) for detection of infectious SARS-CoV-2. Results: The tests were evaluated on nasopharyngeal samples taken from individuals having respiratory and/or COVID-19 related symptoms, which had been analyzed for SARS-CoV-2 RNA using real-time PCR. In total 156 PCR-positive, and 130 (Panbio) and 176 (Orient Gene) PCR-negative samples were analyzed. Overall sensitivity and specificity were 71.8% and 100% for Panbio and 79.5% and 74.4% for the Orient Gene test respectively. The false positives by the Orient Gene test were verified as SARS-CoV-2 negative by in-house real-time PCR assay and were negative for the four seasonal coronaviruses. Subgroup analysis revealed that the antigen tests had high sensitivity for samples with Ct-values <25 (>88%) and for samples containing infectious viruses as determined by cultivation on Vero cells, 94.1% and 97.1% for the Panbio and Orient gene tests, respectively. Furthermore, both tests had a sensitivity of <50 picogram for nucleocapsid protein. No sample with a Ct-value >27 was shown to contain infectious virus. Conclusion: The results indicate that the rapid antigen tests, especially the Panbio tests may be a valuable tool to detect contagious persons during the ongoing pandemic.
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Sharma, SumitLinköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten(Swepub:liu)sumsh85
(författare)
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Olsson, HenrikNoviral Sweden AB, Sweden
(författare)
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Jamtberg, MikaelNoviral Sweden AB, Sweden
(författare)
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Falkeborn, TinaLinköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten,Region Östergötland, Klinisk mikrobiologi(Swepub:liu)tinlu81
(författare)
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Svensson, LennartKarolinska Institutet,Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten,Karolinska Inst, Sweden(Swepub:liu)lensv66
(författare)
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Hagbom, MarieLinköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten(Swepub:liu)marha48
(författare)
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Linköpings universitetAvdelningen för molekylär medicin och virologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Clinical Virology: ELSEVIER1401386-65321873-5967
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