id:"swepub:oai:DiVA.org:liu-180909"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03853naa a2200409 4500 | |
| 001 | oai:DiVA.org:liu-180909 | |
| 003 | SwePub | |
| 008 | 211109s2022 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:147941256 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1809092 URI |
| 024 | 7 | a https://doi.org/10.1007/s00228-021-03234-62 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1479412562 URI |
| 040 | a (SwePub)liud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Söderman, Lisau Karolinska Inst, Sweden4 aut |
| 245 | 1 0 | a Adjuvant use of melatonin for pain management in dysmenorrhea - a randomized double-blinded, placebo-controlled trial |
| 264 | c 2021-10-20 | |
| 264 | 1 | b Springer Heidelberg,c 2022 |
| 338 | a electronic2 rdacarrier | |
| 500 | a Funding Agencies|Karolinska InstituteKarolinska Institutet; Stockholm County CouncilStockholm County Council [20180306]; AFA insurance [170157] | |
| 520 | a Purpose Dysmenorrhea is a common, recurring, painful condition with a global prevalence of 71%. The treatment regime for dysmenorrhea includes hormonal therapies and NSAID, both of which are associated with side effects. A dose of 10 mg melatonin daily has previously been shown to reduce the level of pelvic pain in women with endometriosis. We chose to investigate how this regime, administered during the week of menstruation, would affect women with dysmenorrhea but without any signs of endometriosis, as adjuvant analgesic treatment. Methods Forty participants with severe dysmenorrhea were randomized to either melatonin or placebo, 20 in each group. Our primary outcome was pain measured with numeric rating scale (NRS); a difference of at least 1.3 units between the groups was considered clinically significant. Secondary outcomes were use of analgesics, as well as absenteeism and amount of bleeding. Mixed model was used for statistical analysis. Results Eighteen participants completed the study in the placebo group and 19 in the melatonin group. Mean NRS in the placebo group was 2.45 and 3.18 in the melatonin group, which proved to be statistically, although not clinically significant. Conclusion This randomized, double-blinded, placebo-controlled trial could not show that 10 mg of melatonin given orally at bedtime during the menstrual week had better analgesic effect on dysmenorrhea as compared with placebo. However, no adverse effects were observed. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng |
| 653 | a Adjuvant analgesics; Dysmenorrhea; Melatonin; Menstruation; Pelvic pain; RCT | |
| 700 | 1 | a Edlund, Månsu Karolinska Inst, Sweden4 aut |
| 700 | 1 | a Böttiger, Ylvau Linköpings universitet,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten,Region Östergötland, Klinisk farmakologi4 aut0 (Swepub:liu)ylvbo14 |
| 700 | 1 | a Marions, Lenau Karolinska Institutet4 aut |
| 710 | 2 | a Karolinska Inst, Swedenb Avdelningen för klinisk kemi och farmakologi4 org |
| 773 | 0 | t European Journal of Clinical Pharmacologyd : Springer Heidelbergg 78:2, s. 191-196q 78:2<191-196x 0031-6970x 1432-1041 |
| 856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:1609698/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://link.springer.com/content/pdf/10.1007/s00228-021-03234-6.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-180909 |
| 856 | 4 8 | u https://doi.org/10.1007/s00228-021-03234-6 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:147941256 |
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