Nuclease activity: an exploitable biomarker in bacterial infections

Nuclease activity : an exploitable biomarker in bacterial infections

Garcia Gonzalez, Javier (author): Linköpings universitet,Biologi,Tekniska fakulteten,Wallenberg Centre for Molecular Medicine (WCMM); Nucleic Acids Technologies Laboratory (NAT-lab)

Hernandez, Frank J, 1979- (author): Linköpings universitet,Biologi,Tekniska fakulteten,Molekylär ytfysik och nanovetenskap,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Wallenberg Centre for Molecular Medicine (WCMM); Nucleic Acids Technologies Laboratory (NAT-lab)

(creator_code:org_t)

2022-03-16
2022
English.
In: Expert Review of Molecular Diagnostics. - : Taylor & Francis AS. - 1473-7159 .- 1744-8352. ; 22:3, s. 265-294

Related links:: https://liu.diva-por... (primary) (Raw object); show more...; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Abstract Subject headings

Introduction In the increasingly challenging field of clinical microbiology, diagnosis is a cornerstone whose accuracy and timing are crucial for the successful management, therapy, and outcome of infectious diseases. Currently employed biomarkers of infectious diseases define the scope and limitations of diagnostic techniques. As such, expanding the biomarker catalog is crucial to address unmet needs and bring about novel diagnostic functionalities and applications. Areas covered This review describes the extracellular nucleases of 15 relevant bacterial pathogens and discusses the potential use of nuclease activity as a diagnostic biomarker. Articles were searched for in PubMed using the terms: nuclease, bacteria, nuclease activity or biomarker. For overview sections, original and review articles between 2000 and 2019 were searched for using the terms: infections, diagnosis, bacterial, burden, challenges. Informative articles were selected. Expert opinion Using the catalytic activity of nucleases offers new possibilities compared to established biomarkers. Nucleic acid activatable reporters in combination with different transduction platforms and delivery methods can be used to detect disease-associated nuclease activity patterns in vitro and in vivo for prognostic and diagnostic applications. Even when these patterns are not obvious or of unknown etiology, screening platforms could be used to identify new disease reporters.

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Hematology

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